mucinous carcinoma-associated antigen

used in breast cancer test; test based on monoclonal antibody Mab b12; high MW mucin-like glycoprotein; expressed in high levels by many human adenocarcinomas

Also Known As:

CA M26; CA M26 antigen; CA M29; CA M29 antigen; CAM26; CAM29; MCA (mucin-like carcinoma-associated antigen); breast cancer mucin antigen; ductal carcinoma antigen; ductal carcinoma antigen DCA; mucin-like carcinoma-associated antigen

Networked: 64 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Tumor Biomarkers: 15272
    - Carbohydrate Tumor-Associated Antigens: 355
      - mucinous carcinoma-associated antigen: 64
- Antigens: 143924
  - Epitopes: 19548
    - Carbohydrate Tumor-Associated Antigens: 355
      - mucinous carcinoma-associated antigen: 64
  - Neoplasm Antigens: 6217
    - Carbohydrate Tumor-Associated Antigens: 355
      - mucinous carcinoma-associated antigen: 64

Experts

1.	Protonotariou, Efthimia: 1 article (01/2007)
2.	Rizos, Demetrios: 1 article (01/2007)
3.	Sarandakou, Angeliki: 1 article (01/2007)
4.	Koehl, C: 1 article (07/2006)
5.	Mathelin, C: 1 article (07/2006)
6.	Rio, M-C: 1 article (07/2006)
7.	Abbate, I: 1 article (04/2004)
8.	Coviello, M: 1 article (04/2004)
9.	Daniele, A: 1 article (04/2004)
10.	Durrant, L G: 1 article (04/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 05/01/2001 - "To assess the usefulness of Mucin-like carcinoma-associated antigen (MCA) in monitoring pregnant patients with breast cancer. " 10/01/1997 - "The usefulness of serum measurements of mucin-like carcinoma associated antigen (MCA) in 100 women at presentation with breast cancer was evaluated. " 10/01/1997 - "Mucin-like carcinoma associated antigen (MCA) at presentation with breast cancer." 07/01/1997 - "Increased levels of mucin-like carcinoma-associated antigen (MCA) in breast cancer patients with no evidence of disease following the treatment of the primary disease created a dilemma of 'to treat' or 'wait and see'. " 07/01/1997 - "A high value of mucin-like carcinoma associated antigen (MCA), CA-15.3 or H23, in a woman known to have a diagnosis of breast cancer, may reflect presence of disease. "
2.	Neoplasms (Cancer) 04/01/1993 - "Mucin-like Carcinoma-associated Antigen (MCA) has been associated with many breast cancers. " 07/01/1990 - "For comparison, at the cut-off level of 10 kU/1 the CA M29 test was positive in 30/46 (65%) cancer cases, in 16/20 (80%) of cancer patients with nodal involvement, in 9/49 (18%) of the patients with benign breast disease, and in 10/30 (33%) of control subjects. " 01/01/1990 - "The good SE and the very good SP and diagnostic accuracy of CAM29 could suggest further investigation in order to evaluate the role of this antigen in the management of patients with this malignancy." 06/01/1990 - "To prove, wheather the new tumor marker 'mucin-like carcinoma-associated antigen' could be used for the management of breast cancer patients, we determined its serum concentration in 50 healthy blood donors, 130 patients with various non-malignant diseases, 138 patients with different metastazised tumors and 137 breast cancer patients. " 07/01/2006 - "Nowadays, the most useful biomarkers measure circulating levels of fragments of MUC1-polymorphic epithelial mucin (MUC1-PEM): cancer antigen (CA) 15.3, mucin-like carcinoma-associated antigen (MCA), CA 27-29, CA 549... "
3.	Pleural Effusion (Pleural Effusions) 10/01/2000 - "The aim of the present study was to determine the usefulness of simultaneous quantification of carbohydrate antigen 19.9, carbohydrate antigen 125, neuron specific enolase, mucinous-carcinoma-associated antigen, and ferritin in samples of pleural fluids in the malign pleural effusion and its differentiation from benign effusions. "
4.	Carcinoma (Carcinomatosis) 01/01/1991 - "Clinical value of a mucin-like carcinoma-associated antigen (MCA) in patients with carcinomas of the kidney and the urinary collecting system." 10/01/1990 - "[Determination of MCA, CA 15.3, CA M26, in carcinoma of the breast]." 01/01/1990 - "In conclusion, the present data showed that the measurement of CA15.3, MCA and CAM26 did not give any additional information with respect to CA125 assay in the diagnosis of ovarian carcinoma. " 01/01/1991 - "A new tumor marker, mucin-like carcinoma-associated antigen (MCA), was evaluated in thirty-four patients with renal cell carcinomas and forty patients with carcinomas of the urinary collecting system. " 01/01/1989 - "Pretreatment concentrations of breast carcinoma antigen (CA 15.3) and mucin-like carcinoma-associated antigen in patients with carcinoma of the breast."
5.	Neoplasm Metastasis (Metastasis) 01/01/1991 - "A new tumour marker, mucin-like carcinoma-associated antigen (MCA), was evaluated in 176 breast cancer patients classified either as free of tumour (NED, n = 141) or as having metastases (PD, n = 35). " 07/01/1990 - "When we set the cut-off level at 40 kU/1 for CA M26, 15/46 (33%) of all breast cancer patients, 11/20 (55%) of breast cancer patients with axillary node involvement, 1/1 breast cancer patient with distant metastases, 4/49 (8%) of patients with benign breast disease, and 7/30 (23%) of control subjects were above this cut-off level. " 07/01/1990 - "The determination of mucin like carcinoma associated antigen (MCA) showed a sensitivity of 72% in visceral metastasis of breast cancer, of 25% in metastasis of stomach cancer and of 10.3% in metastasis of colorectal cancer. " 10/01/1996 - "A total of 209 postsurgical breast cancer patients were prospectively monitored with simultaneous serum level estimations of CA 15,3, mucin-like carcinoma-associated antigen (MCA), tumor polypeptide antigen (TPA), and carcinoembryonic antigen (CEA); 141 (67.5%) were free of recurrence and 68 (32.5%) developed metastases during the follow-up. "

Related Drugs and Biologics

1.	mucinous carcinoma-associated antigen
2.	Carcinoembryonic Antigen
3.	Steroid Receptors (Steroid Receptor)
4.	Antigens
5.	Mucins
6.	Carbohydrates
7.	Phosphopyruvate Hydratase (Enolase)
8.	Tamoxifen
9.	Ferritins (Ferritin)
10.	Tumor Biomarkers (Tumor Markers)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Laparotomy