BRL 37344

SB 206606 is the (R,R)-isomer

Also Known As:

(4-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetic acid; 2-(4-((2R)-2-(((2R)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetic acid; BRL 37344, (R*,R*)-(+-)-isomer; BRL 37344A; BRL-37344; BRL-37344 sodium; SB 206606; SB-206606; sodium 2-(4-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxy)acetate

Networked: 18 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - BRL 37344: 18
- Alcohols: 595
  - Ethanol: 23169
    - Ethanolamines: 16
      - BRL 37344: 18
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - BRL 37344: 18

Experts

1.	Gonzaga-Silva, Lúcio Flávio: 2 articles (02/2019 - 08/2018)
2.	Barreira, Márcio Alencar: 1 article (02/2019)
3.	Carvalho, Marcos Fiuza de: 1 article (02/2019)
4.	Fechine, Francisco Vagnaldo Jacuru: 1 article (02/2019)
5.	Oliveira, Ricardo Reges Maia de: 1 article (02/2019)
6.	Pamplona, Thuliermes Lopes: 1 article (02/2019)
7.	Fonteles, Manassés Claudino: 1 article (08/2018)
8.	Linhares, Bruno Lima: 1 article (08/2018)
9.	Marinho, Lucas Bernardo: 1 article (08/2018)
10.	Moraes, Manoel Odorico: 1 article (08/2018)

Related Diseases

1.	Burns 01/01/1999 - "Maximal lipolytic responses to a specific beta(3)-AR agonist, BRL-37344, were significantly attenuated at post burn days (PBD) 3 and 7. Despite significant reduction of the cell surface beta(3)-AR number and its mRNA at PBD 3 and 7, BRL-37344 and forskolin-stimulated cAMP levels were not decreased. "
2.	Fever (Fevers) 07/01/1999 - "The stress-induced fever was mimicked by central nervous system administration of the selective beta2-agonist, salbutamol, and the beta3-agonist, BRL 37344. " 07/01/1999 - "The purpose of this study was to determine the relative contribution of the different beta-receptor types to stress fever using beta1-, beta2-, and beta3-receptor subtype selective antagonists (atenolol [beta1], ICI-118551 [beta2], and SR 59230A [beta3]) and agonists (dobutamine [beta1], salbutamol [beta2], and BRL 37344 [beta3]) on the Tb of rats. "
3.	Overactive Urinary Bladder (Overactive Bladder) 02/28/2019 - "To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. " 02/28/2019 - "Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice1." 08/15/2018 - "The relaxant effect of BRL 37344 was enhanced by rolipram but not by tadalafil, suggesting that PDE4 inhibition, especially when associated with ß3-adrenoceptor stimulation, could represent a potential treatment for overactive bladder."
4.	Hyperthyroidism 01/01/1996 - "White adipocytes from hyperthyroid rats had increased responsiveness (Emax x 2) and sensitivity (+ 38%) to BRL 37344, while those given AM alone had decreased values. " 02/01/2000 - "3. The lipolytic responses to isoprenaline, noradrenaline (beta 1/beta 3/beta 3-AR agonists) and BRL 37344 (beta 3-AR agonist) were potentiated by 48, 58 and 48%, respectively in hyperthyroidism and reduced by about 80% in hypothyroidism. "
5.	Heart Failure 04/01/2014 - "β3-Adrenoreceptor stimulation with BRL-37344 was associated with an increase in LA diameter and a decrease in LA function in chronic heart failure. " 04/01/2014 - "To investigate the effect of selective β3-adrenoreceptor agonist BRL-37344 on L-type Ca(2+) current (Ica,L) and mRNA expression of L-type Ca(2+) channel α2δ-2 (Cacna2d2) in rats with chronic heart failure (CHF). " 06/01/2005 - "To evaluate the effects of different doses of N(G)-nitro-L-arginine methyl ester (L-NAME) on hemodynamics, cyclic guanosine monophosphate (cGMP) production and the level of beta-adrenergic receptors (beta-ARs) mRNA in a heart failure rat model after BRL-37344 (beta(3)-ARs agonist) injection. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Colforsin
3.	Albuterol (Salbutamol)
4.	3- (2- ethylphenoxy)- 1- (1,2,3,4- tetrahydronaphth- 1- ylamino)- 2- propanol oxalate
5.	Dobutamine
6.	Atenolol (Tenormin)
7.	ICI 118551
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Isoproterenol (Isoprenaline)
10.	Norepinephrine (Noradrenaline)