sarafotoxins s6

several isotoxins from Atractaspis engaddensis; has strong cardiotoxic activity; all contain 21 amino acid residues; see also endothelium-derived vasoconstrictor factor, ENDOTHELINS.

Also Known As:

Networked: 45 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Edvinsson, Lars: 2 articles (01/2018 - 07/2004)
2.	Webb, D J: 2 articles (03/2002 - 01/2000)
3.	Araya, Erika Ivanna: 1 article (07/2018)
4.	Chichorro, Juliana Geremias: 1 article (07/2018)
5.	Gomes, Lenyta Oliveira: 1 article (07/2018)
6.	Rae, Giles Alexander: 1 article (07/2018)
7.	de Oliveira, Jade: 1 article (07/2018)
8.	Ansar, Saema: 1 article (01/2018)
9.	Grell, Anne-Sofie: 1 article (01/2018)
10.	Mostajeran, Maryam: 1 article (01/2018)

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/2008 - "However, we recently showed that chronic activation of ET(B)R in rats with the selective agonist sarafotoxin 6c (S6c) causes sustained hypertension. " 01/01/1999 - "These results, together with the lack of relaxation in response to sarafotoxin S6c in SHR, suggest that an imbalance in the endothelin-1 ability to induce both contraction and relaxation is present in SHR with sustained hypertension, manifesting as a greater contractile effect evoked in this strain." 01/01/2018 - "The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. "
2.	Ischemia 08/01/2007 - "The aim of this investigation was to test whether the administration of sarafotoxin 6c(a selective ET(B) receptor agonist) has cardioprotective and antiarrhythmic effects against ischemia and reperfusion injury in a well-standardized model of reperfusion arrhythmias in anesthetized adult male rabbits (n = 53) subjected to 30 min occlusion of the left coronary artery followed by 120 min of reperfusion. " 08/01/2007 - "Sarafotoxin 6c evoked NO release and selective activation of mitoK(ATP) channels in cardiomyocytes contributes to cardioprotection and antiarrhythmic activity during ischemia-reperfusion in the anesthetized rabbit. " 01/01/1995 - "Responses to endothelins-1, -2, and -3 and sarafotoxin 6c after ischemia/reperfusion in isolated perfused rat heart: role of vasodilator loss." 08/01/2007 - "Pretreatment with sarafotoxin 6c prior to coronary occlusion protects against infarction and arrhythmias via cardiomyocyte mitochondrial K(ATP) channel activation in the intact rabbit heart during ischemia/reperfusion." 08/01/2007 - "Endothelial ET(B) receptor activation by exogenously administered sarafotoxin 6c(a snake venom peptide with a sequence homology to ET-1 prior to ischemia activates release of nitric oxide(NO) and previous studies have shown that NO facilitates mitochondrial K(ATP) activation in cardiac cells and cardioprotection. "
3.	Stroke (Strokes) 01/01/2018 - "The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. "
4.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2018 - "The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph. "
5.	Right Ventricular Dysfunction 11/01/2016 - "A recent in vivo study on anesthetized and ventilated animals showed that sarafotoxin-b (SRTX-b), extracted from the venom of Atractaspis engaddensis, decreases cardiac output by inducing left ventricular dysfunction while sarafotoxin-m (SRTX-m), extracted from the venom of Atractaspis microlepidota microlepidota, induces right ventricular dysfunction with increased airway pressure. "

Related Drugs and Biologics

1.	Endothelin-1 (Endothelin 1)
2.	Endothelins (Endothelin)
3.	Peptides (Polypeptides)
4.	Endothelin B Receptor
5.	Endothelin Receptors (Endothelin Receptor)
6.	Snake Venoms (Snake Venom)
7.	Venoms
8.	Messenger RNA (mRNA)
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Angiotensin II

Related Therapies and Procedures

1.	Intravenous Administration
2.	Cystectomy
3.	Resuscitation
4.	Injections
5.	Intravenous Infusions