cisplatin-DNA adduct

01/01/1999 - "By combining these data, we estimated that approximately 25-fold more GADD153 per cisplatin-DNA adduct was induced in tumor cells than in stromal cells. "
01/01/1992 - "[Use of polyplatillen in the treatment of stage IV malignant neoplasms]."
04/01/2007 - "Polyplatillen improves the tumor response, general and relapse-free survival of advanced small cell lung cancer treatment in comparance with traditional VEC scheme."
08/15/2006 - "In conclusion, cisplatin-DNA adduct formation in primary tumor appears to be predictive for DFS in HNSCC. "
03/17/2021 - "Corroborating this finding, cisplatin delivery to the 4T1 primary tumor was enhanced upon OMO-1 treatment, increasing cisplatin DNA-adduct levels and tumor cell death. "

06/15/2010 - "Using a mouse model of human cervical cancer, we demonstrate that combined treatment with a copper chelator and cisplatin increases cisplatin-DNA adduct levels in cancerous but not in normal tissues, impairs angiogenesis, and improves therapeutic efficacy. "

08/15/2006 - "In conclusion, cisplatin-DNA adduct formation in primary tumor appears to be predictive for DFS in HNSCC. "
08/15/2006 - "The purpose of our study was to test the predictive value of cisplatin-DNA adduct levels in head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin-radiation. "
01/01/2013 - "Our findings suggest that the cisplatin-DNA adduct level is the most important determinant of cisplatin sensitivity in HNSCC cells. "
08/15/2006 - "Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-radiation (RADPLAT)."
01/01/1999 - "Total platinum contents and cisplatin-DNA adduct levels were determined in vivo in xenografted tumour tissues in mice and in vitro in cultured tumour cells of head and neck squamous cell carcinoma (HNSCC), and correlated with sensitivity to cisplatin. "

11/01/1992 - "[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)]."

09/01/2007 - "[Chemotherapy of the small cell lung cancer using polyplatillen]."
04/01/2007 - "In the article authors summarize the experience of new anticancer drug polyplatillen usud in the chemoradiotherapy of small cell lung cancer. "
04/01/2007 - "[Results of palliative chemoradiotherapy of advanced small cell lung cancer using polyplatillen]."
04/01/2007 - "Polyplatillen improves the tumor response, general and relapse-free survival of advanced small cell lung cancer treatment in comparance with traditional VEC scheme."