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N-nitroso-N(2)-fluorenylacetamide (NN-FAT)
Also Known As:
NN-FAT
; N-nitroso-2-acetylaminofluorene; N-nitroso-2-fluorenylacetamide
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Acetamides: 21
2-Acetylaminofluorene: 525
N-nitroso-N(2)-fluorenylacetamide: 3
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
2-Acetylaminofluorene: 525
N-nitroso-N(2)-fluorenylacetamide: 3
Carboxylic Acids: 973
Acyclic Acids
Acetates: 4994
Acetamides: 21
2-Acetylaminofluorene: 525
N-nitroso-N(2)-fluorenylacetamide: 3
Nitroso Compounds: 446
N-nitroso-N(2)-fluorenylacetamide: 3
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Fluorenes: 7
2-Acetylaminofluorene: 525
N-nitroso-N(2)-fluorenylacetamide: 3
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
07/01/1995 - "
In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas (HCCs) induced by N-nitroso-2-acetylaminofluorene (NO-AAF) and 2-acetylaminofluorene (AAF) were 19.23% (20 of 104) and 31.1% (33 of 106), respectively.
"
07/01/1995 - "
p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
"
2.
Chromosome Aberrations (Chromosome Abnormalities)
02/01/1992 - "
The frequencies of chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in Chinese hamster cells were significantly increased by the direct-acting mutagen N-nitroso-2-acetylaminofluorene (N-NO-AAF) at the concentration of 0.1 mM. N-NO-AAF was prepared by nitrosation of the protohepatocarcinogen 2-acetylaminofluorene.
"
02/01/1992 - "
Chromosomal aberrations and sister-chromatid exchanges induced by N-nitroso-2-acetylaminofluorene and their modifications by arsenite and selenite in Chinese hamster ovary cells.
"
3.
Body Weight (Weight, Body)
08/01/1994 - "
To compare the hepatotoxicity and hepatocarcinogenicity of N-nitroso-2-acetylaminofluorene (NO-AAF) and its parent compound, 2-acetylaminofluorene (AAF), male Sprague-Dawley rats were given intraperitoneal (i.p.) or subcutaneous (s.c.) injections of AAF or NO-AAF (60 mg/kg body weight/week) for ten months.
"
Related Drugs and Biologics
1.
2-Acetylaminofluorene (2 Acetylaminofluorene)
2.
Selenious Acid (Selenite)
3.
Mutagens
4.
arsenite
Related Therapies and Procedures
1.
Injections