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N-nitroso-N(2)-fluorenylacetamide (NN-FAT)

Also Known As:

NN-FAT; N-nitroso-2-acetylaminofluorene; N-nitroso-2-fluorenylacetamide

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 07/01/1995 - "In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas (HCCs) induced by N-nitroso-2-acetylaminofluorene (NO-AAF) and 2-acetylaminofluorene (AAF) were 19.23% (20 of 104) and 31.1% (33 of 106), respectively. " 07/01/1995 - "p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats."
2.	Chromosome Aberrations (Chromosome Abnormalities) 02/01/1992 - "The frequencies of chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in Chinese hamster cells were significantly increased by the direct-acting mutagen N-nitroso-2-acetylaminofluorene (N-NO-AAF) at the concentration of 0.1 mM. N-NO-AAF was prepared by nitrosation of the protohepatocarcinogen 2-acetylaminofluorene. " 02/01/1992 - "Chromosomal aberrations and sister-chromatid exchanges induced by N-nitroso-2-acetylaminofluorene and their modifications by arsenite and selenite in Chinese hamster ovary cells."
3.	Body Weight (Weight, Body) 08/01/1994 - "To compare the hepatotoxicity and hepatocarcinogenicity of N-nitroso-2-acetylaminofluorene (NO-AAF) and its parent compound, 2-acetylaminofluorene (AAF), male Sprague-Dawley rats were given intraperitoneal (i.p.) or subcutaneous (s.c.) injections of AAF or NO-AAF (60 mg/kg body weight/week) for ten months. "

Related Drugs and Biologics

1.	2-Acetylaminofluorene (2 Acetylaminofluorene)
2.	Selenious Acid (Selenite)
3.	Mutagens
4.	arsenite

Related Therapies and Procedures

1.	Injections