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ebiratide
analog of ACTH 4-9; RN given in USAN; RR given in Toxlit 10/88
Also Known As:
Hoe 427; Hoe-427; L-Methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)-L-phenylalaninamide S,S-dioxide; Met-O2-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2
Networked:
5
relevant articles (
2
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Peptides: 82426
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Hypothalamic Hormones: 68
Pro-Opiomelanocortin: 1936
Melanocortins: 946
Adrenocorticotropic Hormone: 16568
ebiratide: 5
Peptide Fragments: 373
ebiratide: 5
Related Diseases
1.
Alzheimer Disease (Alzheimer's Disease)
01/01/1995 - "
Thus, the present study indicates that ebiratide shares neurotrophic properties which may prove beneficial in the therapy for CNS degenerative disorders, especially Alzheimer's disease.
"
06/01/1993 - "
In an acute trial, three different dosages (60, 300, and 600 micrograms) of the endocrinologically inert but behaviorally active corticotropin 4-9 (ACTH4-9) fragment ebiratide were given to three patients with clinically probable Alzheimer's disease and five patients with a major depressive episode who were psychomotorly retarded.
"
01/01/1991 - "
First clinical impressions with an ACTH analog (HOE 427) in the treatment of Alzheimer's disease.
"
2.
Amnesia (Dissociative Amnesia)
05/01/1988 - "
With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.
"
3.
Spinal Cord Injuries (Spinal Cord Injury)
08/01/1997 - "
Blood-brain barrier permeability to ebiratide and TNF in acute spinal cord injury.
"
Related Drugs and Biologics
1.
Scopolamine (Hyoscine)
2.
Adrenocorticotropic Hormone (ACTH)
Related Therapies and Procedures
1.
Therapeutics