periplocoside A

isolated from Periploca sepium; structure given in first source; MF: C72-H114-O27

Also Known As:

2H-Pyran-3(6H)-one, 2-(((3beta,20S)-20-((5-((O-2-O-acetyl-6-deoxy-3-O-methyl-beta-D-galactopyranosyl-(1-4)-O-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl)oxy)tetrahydro-4-methoxy-6,9'-dimethylspiro(2H-pyran-2,3'(4'H)-(7H)pyrano(3-,4-c)(1,2,5)trioxepin)-7'-yl)oxy)-17-hydroxypregn-5-en-3-yl)oxy)--4-methoxy-6-methyl-,(3'S-(3'alpha(4S*,5S*,6S*),5'abeta,7'alpha(6S*),9'alpha,9'aalpha)-)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tang, Wei: 3 articles (03/2017 - 09/2008)
2.	Ni, Jia: 2 articles (08/2009 - 09/2008)
3.	Zhang, Jing: 2 articles (08/2009 - 09/2008)
4.	Cheng, Lei: 1 article (03/2017)
5.	Hu, Xudong: 1 article (03/2017)
6.	Yang, Yang: 1 article (03/2017)
7.	Yang, Yifu: 1 article (03/2017)
8.	Zhao, Weimin: 1 article (03/2017)
9.	Zuo, Jianping: 1 article (03/2017)
10.	Chen, Zhen-hua: 1 article (08/2009)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/01/2009 - "Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells." 08/01/2009 - "The aim of this study was to determine the therapeutic effect of Periplocoside A (PSA), a natural product isolated from the traditional Chinese herbal medicine Periploca sepium Bge, in MOG(35-55) (myelin oligodendrocyte glycoprotein 35-55)-induced experimental autoimmune encephalomyelitis (EAE). "
2.	Hepatitis 09/01/2008 - "Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions."
3.	Rheumatoid Arthritis 03/01/2017 - "Periplocoside A (PSA) has been extracted from the Chinese herbal medicine Periploca sepium Bge to treat rheumatoid arthritis (RA) via immune regulation. "
4.	Arthritis (Polyarthritis) 03/01/2017 - "Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	myelin oligodendrocyte glycoprotein (35-55)
3.	Collagen Type II (Type II Collagen)
4.	Interleukin-17 (Interleukin 17)
5.	Cytokines
6.	Concanavalin A
7.	pregnane glycoside

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