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FR 50948
RN given refers to parent cpd
Also Known As:
10-((2,3-dimethyl-1-oxopentyl)amino)-4-oxo-4H-pyrimido(1,2-c)quinazoline-3-carboxylic acid; FR 50948, sodium salt; FR-50948; FR50948
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
FR 50948: 1
Related Diseases
1.
Inflammation (Inflammations)
04/01/1988 - "
FR50948 also had weak inhibitory effects on inflammation (carrageenin paw edema and adjuvant arthritis) and SRS release from rat neutrophils, but no antagonistic effects to histamine and serotonin.
"
2.
Hypersensitivity (Allergy)
04/01/1988 - "
FR50948 had inhibitory effects on type I and type III allergic reactions, but not on type II and IV allergic reactions.
"
04/01/1988 - "
The inhibitory effect of FR50948 on IgE-mediated type I allergic reactions was essentially the same as those of SCG and lodoxamide, because FR50948 inhibited the histamine release from rat peritoneal mast cells and had cross tachyphylaxis with SCG in the rat PCA test.
"
3.
Edema (Dropsy)
04/01/1988 - "
FR50948 also had weak inhibitory effects on inflammation (carrageenin paw edema and adjuvant arthritis) and SRS release from rat neutrophils, but no antagonistic effects to histamine and serotonin.
"
4.
Experimental Arthritis
04/01/1988 - "
FR50948 also had weak inhibitory effects on inflammation (carrageenin paw edema and adjuvant arthritis) and SRS release from rat neutrophils, but no antagonistic effects to histamine and serotonin.
"
Related Drugs and Biologics
1.
Serotonin (5 Hydroxytryptamine)
2.
Immunoglobulin E (IgE)
3.
Histamine (Histamine Dihydrochloride)
4.
Carrageenan
5.
lodoxamide ethyl (lodoxamide)