2,7-diaminomitosene

02/01/2005 - "2,7-Diaminomitosene (2,7-DAM) is the major metabolite of MC in tumor cells, generated by the reduction of MC. "
01/01/2016 - "2,7-Diaminomitosene (2,7-DAM) is a major metabolite of MC in tumor cells, which also alkylates DNA. "
10/25/2002 - "The various DNA adducts formed upon treatment of mouse mammary tumor cells with MC as well as 10-decarbamoyl MC (DMC) and 2,7-diaminomitosene (2,7-DAM), the major MC metabolite, have been elucidated. "
01/01/1998 - "Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C."
09/04/2001 - "2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C, forms DNA adducts in tumor cells. "

01/01/1995 - "The progress of mitomycin C (MMC) bioreduction was studied in vivo in the rat Sp 107 mammary carcinoma after intra-tumoural injection of either 100 micrograms or 1 mg. 2,7-Diaminomitosene (2,7-DM) was utilised as a primary bioreductive metabolite and 10-decarbamoyl 2,7-diaminomitosene (DC 2,7-DM) served as a secondary bioreductive metabolite, both of which were measured by high-performance liquid chromatography. "

08/15/2005 - "The MC metabolite profiles were confirmed using purified human cytochrome P450 reductase, acidic activation, and UV-Vis detection at 550 nm. In hypoxia, MC was exclusively metabolized into 2,7-diaminomitosene-10-glutathione-S-conjugate (2,7-DAM-10-SG) within 30 min, whereas approximately 5% of this conjugate, 16% of 2,7-diaminomitosene (2,7-DAM), and 77% of MC were observed under a fully aerobic condition at 90 min. Under limitedly aerobic conditions, the relative percentages of the two metabolites in incubations varied greatly depending on the volume ratio of air to liquid. "