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calponin

binds tropomyosin; RefSeq NM_009922 (mouse), NM_001299 (human), NM_031747 (rat)

Also Known As:

CNN1 protein, human; Calponin H1 protein, human; Cnn1 protein, mouse; Cnn1 protein, rat; SMCC protein, human; Sm-Calp protein, human; calponin 1 protein, mouse; calponin 1 protein, rat; calponin 1, basic, smooth muscle protein, human; calponin 3 protein, human; calponin h1 protein, mouse; calponin-h1

Networked: 250 relevant articles (5 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takahashi, Katsuhito: 6 articles (01/2013 - 02/2002)
2.	Yamamura, Hisako: 6 articles (01/2013 - 02/2002)
3.	Reymundo, C: 5 articles (07/2011 - 03/2002)
4.	Ehara, Takashi: 5 articles (04/2010 - 08/2002)
5.	Taniguchi, Shun'ichiro: 5 articles (04/2010 - 08/2002)
6.	Hisaoka, Masanori: 4 articles (12/2012 - 03/2007)
7.	Millán, Y: 4 articles (07/2011 - 03/2004)
8.	Kreipke, Christian W: 4 articles (02/2009 - 05/2006)
9.	Ehara, T: 4 articles (05/2008 - 10/2001)
10.	Taniguchi, S: 4 articles (05/2008 - 10/2001)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2015 - "Although several studies have demonstrated the tumor suppressive function of CNN1 (calponin 1), no studies have performed a site-specific analysis of CNN1 on tumor cell activities. " 12/01/2005 - "In addition, with immunohistochemical studies, the tumor cells were stained for calponin but not for cluster differentiation (CD)-31, CD-34, alpha-smooth muscle actin or S-100." 05/15/2001 - "In this study, we show that expression of the calponin gene in human soft tissue and bone tumor cells is regulated at the transcriptional level by the sequence between positions -260 and -219 upstream of the translation initiation site. " 11/01/2015 - "Loss of myoepithelial calponin was specifically associated with gain of the basal marker p63 in adjacent tumor cells. " 01/01/2015 - "It is useful to recognize the two-cell populations constituting this tumor: small, dark, basaloid cells with hyperchromatic nuclei, which are immunoreactive for P63 and calponin, and larger cells with a pale nucleus, often near the center of the cluster (inner cells), which are immunoreactive for CK7 and CD117 (C-kit). "
2.	Leiomyosarcoma 05/05/1999 - "In this study, we sought to assess the effects (in vitro and in vivo) of increasing calponin h1 expression in leiomyosarcoma cells. " 06/21/2012 - "Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1." 09/01/2002 - "D12CALP also revealed the cell-specific replication to leiomyosarcoma in which calponin expression was augmented. " 05/05/1999 - "In assays of anchorage-independent growth and in vivo tumorigenicity, both growth and tumorigenicity were statistically significantly reduced in calponin h1-transfected leiomyosarcoma cells. " 07/01/1998 - "Reduced expression of calponin h1 in leiomyosarcoma of the uterus."
3.	Noninfiltrating Intraductal Carcinoma (DCIS) 01/01/2011 - "Our results demonstrated that using FAP-α and Calponin adjunctively improved the sensitivity of pathological diagnosis of DCIS-MI by 11.29%, whereas the adjunctive use of FAP-α and Calponin improved the sensitivity of pathological diagnosis of DCIS by 13.6%. " 01/01/2011 - "This study provides the first evidence that immunostaining with FAP-α and Calponin can serve as a novel marker for pathologically diagnosing whether DCIS has microinvasion." 11/01/2015 - "These results suggest that further research is warranted into the role of myoepithelial cell p63 and calponin expression on DCIS progression to invasive disease. " 11/01/2015 - "Progressive loss of the myoepithelial cell differentiation markers p63, calponin, and α-smooth muscle actin was observed in the mouse myoepithelium surrounding DCIS-involved ducts. " 10/01/2015 - "There was a decrease in expression of CK14, p63, and calponin in pure DCIS-associated myoepithelial cells compared with normal breast tissue myoepithelial cells (43.3% vs. 80.3%, 3.3% vs. 70%, 46.6 vs. 93.3%, respectively) and in the DCIS component of IDC compared with normal breast tissue myoepithelial cells (56.6% vs. 100%, 3.3% vs. 73.3%, 56.6% vs. 96.6%, respectively). "
4.	Fibroma (Fibromatosis) 04/01/2014 - "Anti-calponin 1 antibodies highlight intracytoplasmic inclusions of infantile digital fibromatosis." 04/01/2006 - "Thirty-eight of 42 cases of fibromatosis were positive for SMA, 42/42 cases were positive for calponin, 39/42 cases were negative for SMMS, and all cases were negative for h-caldesmon. " 02/01/2007 - "Calponin expression was detected in 89.3% of canine and 100% of human genital tract tumours diagnosed as leiomyomas, as well as in the majority of other tumours examined (canine or human, genital or extragenital, benign or malignant) with the exception of canine negative control tumours (cutaneous fibroma and hepatoid gland adenoma). " 07/01/2009 - "A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas." 07/01/2009 - "Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. "
5.	Neointima 07/01/2004 - "(3) In actively growing V (AV), alpha-SM actin, calponin and vinculin were 3-, 3.3- and 2.9-fold lower, respectively, in the neointima as compared to the media. " 11/01/1998 - "The most obvious difference with normal vessels is the reiteration of an embryonal expression pattern in smooth muscle cells of the neointima which includes a significant reduction of desmin and alpha-smooth muscle actin, calponin and vinculin. " 10/01/2013 - "We confirmed the sirolimus-mediated increase of migration from the adventitial into the intima side using an ex vivo decellularized vessel scaffold, where they form neointima-like lesions that expressed high levels of smooth muscle cell (SMC) markers (SM-22α and calponin). " 07/01/2004 - "Our findings indicate that induction of Cx37 and reduction of desmin precede the phenotypic changes of SMCs, which are characterized by down-regulation of alpha-SM actin, calponin and vinculin, and the formation of a neointima. " 05/01/2010 - "Carotid ligation in mice with genetic reduction of PTEN specifically in SMC (SMC-specific PTEN heterozygotes) resulted in enhanced neointima formation, increased SMC hyperplasia, reduced SM-alpha-actin and calponin expression, and increased NF-kappaB and cytokine expression compared with wild-types. "

Related Drugs and Biologics

1.	Desmin
2.	Tropomyosin
3.	Vinculin
4.	Peptides
5.	Myosin Heavy Chains (Myosin Heavy Chain)
6.	Calmodulin-Binding Proteins (Caldesmon)
7.	Vimentin
8.	Antibodies
9.	Progesterone Receptors (Progesterone Receptor)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Ligation
2.	Heterologous Transplantation (Xenotransplantation)