gardenoside

structure given in first source; RN given refers to 1S(1alpha,4alpha,7alpha,7aalpha)-isomer

Also Known As:

gardenoside, 1S(1alpha,4alplha,7beta,7alpha); Cyclopenta(c)pyran-4-carboxylicacid, 1-(b-D-glucopyranosyloxy)-1,4a,7,7a-tetrahydro-7-hydroxy-7-(hydroxymethyl)-,methyl ester, (1S,4aS,7S,7aS)-

Networked: 7 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Lin: 1 article (01/2021)
2.	Lei, Tao: 1 article (01/2021)
3.	Shen, Tian: 1 article (01/2021)
4.	Wang, Hong-Ping: 1 article (01/2021)
5.	Xu, Bi-Lin: 1 article (01/2021)
6.	Zhang, Cui-Ping: 1 article (01/2021)
7.	Zhu, Bing-Bing: 1 article (01/2021)
8.	Du, Muying: 1 article (03/2020)
9.	Hegyi, Ferenc: 1 article (03/2020)
10.	Mu, Jianfei: 1 article (03/2020)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 01/01/2021 - "A mouse NAFLD model was established, and the effect of gardenoside on both the cell and mouse models of NAFLD was also investigated. " 01/01/2021 - "Importantly, CTCF silencing or DPP4 silencing exhibited effects similar to gardenoside treatment, while CTCF overexpression counteracted this trend, which indicated that CTCF might be a target responsible for gardenoside-induced alleviation of NAFLD, such therapeutic effects might be achieved through controlling the expression of the direct target of CTCF (DPP4) and several downstream molecules. " 01/01/2021 - "Regulatory roles of both CCCTC-binding factor (CTCF) and dipeptidyl peptidase-4 (DPP4) have been reported in NAFLD, but it is still unclear whether the mechanism of action of gardenoside, a potential therapeutic for NAFLD, can be driven via these proteins. " 01/01/2021 - "Gardenoside treatment effectively reduced the lipid accumulation, increased cell viability, reduced reactive oxygen species (ROS) generation, and attenuated pyroptosis and apoptosis in NAFLD in the in vitro and in vivo models. "
2.	Inflammation (Inflammations) 01/01/2023 - "Gardenoside ameliorates inflammation and inhibits ECM degradation in IL-1β-treated rat chondrocytes via suppressing NF-κB signaling pathways."
3.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 07/15/2013 - "Our previous studies showed that after oral administration of an Huang-Lian-Jie-Du-Tang (HLJDT) decoction, there is a higher concentration of the pure components, berberine, baicalin and gardenoside in the plasma of Middle cerebral artery occlusion (MCAO) rats than in sham-operated rats, The aim of the present study was to determine whether these components could be reliably measured in MCAO rat tissues. "
4.	Constipation 03/06/2020 - "This study also confirmed that KFY02 has similar relieving effects to gardenoside for constipation in mice." 03/06/2020 - "Lactobacillus plantarum KFY02 enhances the relieving effect of gardenoside on montmorillonite induced constipation in mice." 03/06/2020 - "Comparatively, the effects of KFY02 (0.5 × 108 CFU kg-1, by body weight (BW)), gardenoside (50 mg kg-1, BW), and KFY02 (0.5 × 108 CFU kg-1, BW) + gardenoside (50 mg kg-1, BW) on intestinal regulation in mice with montmorillonite-induced constipation were also studied. "
5.	Sciatica (Sciatic Neuralgia) 06/01/2018 - "We found out that gardenoside could significantly improve the sciatica by partially restore the decrease of MWT and TWL in CCI rats. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	CCCTC-Binding Factor
3.	Berberine
4.	oren gedoku to
5.	huang-lien-chieh-tu-tang
6.	baicalin
7.	salicylhydroxamic acid (SHAM)
8.	Therapeutic Uses
9.	Sirolimus (Rapamycin)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Oral Administration