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mitomycin C-DNA adduct

complex of mitomycin C and DNA from Micrococcus luteus; structure given in first source

Also Known As:

MC-DNA

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Hong-Yan: 1 article (04/2022)
2.	Gao, Xu-Xia: 1 article (04/2022)
3.	Lu, Da-Ru: 1 article (04/2022)
4.	Ma, Shuang-Ping: 1 article (04/2022)
5.	Song, Xian-Min: 1 article (04/2022)
6.	Wang, Wen-Juan: 1 article (04/2022)
7.	Yang, Jing-Min: 1 article (04/2022)
8.	Zhang, Hao-Kun: 1 article (04/2022)
9.	Zhou, Guo-Qiang: 1 article (04/2022)
10.	Boncristiani, Humberto: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 04/30/2022 - "Furthermore, fragments derived from lentiviral vectors, but not MC DNA, were highly enriched in promoter, exon, intron, distal-intergenic, and cancer-associated genes, indicating that MC DNA provided a relatively safe and efficient vector for delivering transgenes. " 11/01/1993 - "6-CH3-3H-Mitomycin C (MC) was used to identify MC-DNA adducts formed in EMT6 mouse mammary tumor cells. " 06/01/2000 - "Treatment of EMT6 mouse mammary tumor cells with mitomycin C (MC) results in the formation of six major MC-DNA adducts. " 12/01/2019 - "In this study, delivery vehicles comprised of microvesicles loaded with engineered minicircle (MC) DNA that encodes prodrug converting enzymes developed as a cancer therapy in mammary carcinoma models. "
2.	Carcinoma (Carcinomatosis) 12/01/2019 - "In this study, delivery vehicles comprised of microvesicles loaded with engineered minicircle (MC) DNA that encodes prodrug converting enzymes developed as a cancer therapy in mammary carcinoma models. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2014 - "However, delivery of therapeutic genes via a liposome-mediated, MC DNA complex has never been tested in vascular-rich hepatocellular carcinoma (HCC). " 03/01/2010 - "The abilities of the dihydropyridine calcium channel blocker nicardipine (Nic) to induce cytochrome P450 1 family enzymes (CYP1s) and to enhance the 3-methylcholanthrene (MC)-mediated induction of CYP1s and formation of MC-DNA adduct were examined in the human hepatoma cell line HepG2. "
4.	Hypoxia (Hypoxemia) 02/14/2003 - "The marked increase in drug sensitivity under hypoxia at 10 microm MC corresponded to a measurable increase in total MC-DNA adducts at the same concentration. " 11/01/1993 - "The MC-DNA adduct frequencies in DIC-treated cells were increased 1.5-fold under hypoxia and decreased 1.6-fold under aerobic conditions from those observed without DIC. "
5.	Hypopigmentation (Hypomelanosis) 09/01/2014 - "The MC-DNA vector normalized blood phenylalanine concomitant with reversion of hypopigmentation in a dose-dependent manner for more than 1 year, whereas the corresponding parental plasmid did not result in any phenylalanine clearance. "

Related Drugs and Biologics

1.	Enzymes
2.	Prodrugs
3.	Mitomycin (Mitomycin-C)
4.	Polyethyleneimine
5.	Phenylalanine (L-Phenylalanine)
6.	Nicardipine (Dagan)
7.	Methylcholanthrene
8.	Liposomes (Liposome)
9.	Globins
10.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy