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neurokinin A(4-10)
bronchospastic agent
Also Known As:
NKA-(4-10)
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Neuropeptides: 6772
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Oligopeptides: 519
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Peptide Fragments: 373
neurokinin A(4-10): 4
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Kinins: 2029
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Inflammation Mediators: 1113
Autacoids: 276
Kinins: 2029
Tachykinins: 869
Neurokinin A: 269
neurokinin A(4-10): 4
Related Diseases
1.
Peptic Ulcer (Peptic Ulcers)
03/01/1990 - "
Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats.
"
2.
Hypotension (Low Blood Pressure)
06/01/1991 - "
By contrast, MEN 10,376 was devoid of significant agonist activity at i.v. doses (1-3 mumol/kg) which selectively antagonized the effects of an NK-2 agonist [beta-Ala8]-neurokinin A(4-10) (bladder contraction in rats, bronchoconstriction in guinea pigs) without affecting the response to an NK-1 agonist [Sar9]-substance P sulfone (hypotension, salivation and bladder contraction in rats, bronchoconstriction in guinea pigs).
"
3.
Carcinoid Tumor (Carcinoid)
08/03/1987 - "
Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour.
"
4.
Bronchial Spasm
02/20/1990 - "
[beta Ala8]Neurokinin A-(4-10) was as active as, or more active than, neurokinin A (NKA) or NKA-(4-10) in producing rat bladder contraction or bronchospasm in guinea-pigs, two effects known to involve activation of NK-2 receptors.
"
Related Drugs and Biologics
1.
Neurokinin A
2.
Neurokinin-2 Receptors (Neurokinin 2 Receptor)
3.
Sulfones
4.
Substance P
5.
NK 2 (NK-2)