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neurokinin A(4-10)

bronchospastic agent

Also Known As:

NKA-(4-10)

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Tachykinins: 869
        Neurokinin A: 269
        neurokinin A(4-10): 4
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Tachykinins: 869
        Neurokinin A: 269
        neurokinin A(4-10): 4
- Peptides: 82426
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Kinins: 2029
    - Tachykinins: 869
      - Neurokinin A: 269
        neurokinin A(4-10): 4
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Kinins: 2029
      - Tachykinins: 869
        Neurokinin A: 269
        neurokinin A(4-10): 4

Related Diseases

1.	Peptic Ulcer (Peptic Ulcers) 03/01/1990 - "Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats."
2.	Hypotension (Low Blood Pressure) 06/01/1991 - "By contrast, MEN 10,376 was devoid of significant agonist activity at i.v. doses (1-3 mumol/kg) which selectively antagonized the effects of an NK-2 agonist [beta-Ala8]-neurokinin A(4-10) (bladder contraction in rats, bronchoconstriction in guinea pigs) without affecting the response to an NK-1 agonist [Sar9]-substance P sulfone (hypotension, salivation and bladder contraction in rats, bronchoconstriction in guinea pigs). "
3.	Carcinoid Tumor (Carcinoid) 08/03/1987 - "Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour."
4.	Bronchial Spasm 02/20/1990 - "[beta Ala8]Neurokinin A-(4-10) was as active as, or more active than, neurokinin A (NKA) or NKA-(4-10) in producing rat bladder contraction or bronchospasm in guinea-pigs, two effects known to involve activation of NK-2 receptors. "

Related Drugs and Biologics

1.	Neurokinin A
2.	Neurokinin-2 Receptors (Neurokinin 2 Receptor)
3.	Sulfones
4.	Substance P
5.	NK 2 (NK-2)