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5-(N-methyl-N-isobutyl)amiloride

inhibitor of the Na+-H+ antiporter

Also Known As:

5-NMNIA; methylisobutylamiloride

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - Amiloride: 1400
      - 5-(N-methyl-N-isobutyl)amiloride: 3

Experts

1.	Anderson, S E: 1 article (05/2003)
2.	Cala, P M: 1 article (05/2003)
3.	Ho, H S: 1 article (05/2003)
4.	Lewis, E J: 1 article (05/2003)
5.	Liu, H: 1 article (05/2003)

Related Diseases

1.	Ischemia 10/15/1999 - "Hearts treated with the Na(+)/H(+) exchange inhibitor 5-(N-methyl-N-isobutyl)amiloride (MIA) also showed an enhanced recovery after ischemia (DP 62+/-9%). "
2.	Hypoxia (Hypoxemia) 05/01/2003 - "Increases in Na(i) and [Ca](i) were inhibited by the Na(+)/H(+) exchange inhibitor methylisobutylamiloride (MIA, 40 microM; P < 0.05), as well as by increasing perfusate osmolarity (+30 mosM) immediately before and during hypoxia (P < 0.05). "
3.	Acidosis 02/01/1995 - "The aim was to examine the effects of the Na+/H+ exchange inhibitor methylisobutylamiloride (MIA) as well as protein kinase C, a putative regulator of Na+/H+ exchange, on intracellular calcium, intracellular pH, and unloaded cell shortening in isolated guinea pig cardiac myocytes subjected to lactic acid induced acidosis followed by realkalinisation. "

Related Drugs and Biologics

1.	Lactic Acid (Lactate)
2.	Protein Kinase C
3.	Calcium