epithelium-derived relaxant factor

biological factors released by airway epithelium; modulates the responsiveness of the underlying smooth muscle to spasmogens; may be a cyclooxygenase product of arachidonic acid metabolism

Also Known As:

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Adcock, Ian M: 1 article (01/2021)
2.	Huang, Mao: 1 article (01/2021)
3.	Jia, Man: 1 article (01/2021)
4.	Jiang, Jie: 1 article (01/2021)
5.	Meng, Yaqi: 1 article (01/2021)
6.	Ou, Yingwei: 1 article (01/2021)
7.	Wu, Yunhui: 1 article (01/2021)
8.	Xu, Jiayan: 1 article (01/2021)
9.	Yan, Xiaoyi: 1 article (01/2021)
10.	Yang, Yi: 1 article (01/2021)

Related Diseases

1.	Respiratory Hypersensitivity 01/01/2021 - "Airway hyperresponsiveness results from enhanced airway smooth muscle (ASM) contraction potentially under the control of an epithelium-derived relaxing factor (EpDRF). " 09/01/1988 - "This study tested the hypothesis that airway hyperresponsiveness after inhalation of ozone in dogs results from an inability to produce EpDRF. " 09/01/1988 - "These results demonstrate that EpDRF is released from canine tracheal epithelium, that this function is not impaired in dogs with airway hyperresponsiveness after inhaled ozone, and that loss of EpDRF is not responsible for the development of airway hyperresponsiveness after inhaled ozone in dogs."
2.	Inflammation (Inflammations) 03/08/2004 - "On the other hand, airway inflammation induced by intratracheal lipopolysaccharide attenuated the synthesis/release of EpDRF without altering the epithelium morphology." 03/08/2004 - "This study investigated the effects of airway inflammation elicited by intraperitoneal and intratracheal lipopolysaccharide administration to guinea pigs on the activity of tracheal epithelium-derived relaxant factor (EpDRF). "
3.	Hypoxia (Hypoxemia) 01/01/1993 - "Hypoxia could cause the production of an epithelium-derived relaxing factor (EpDRF), which acted directly on smooth muscle. "

Related Drugs and Biologics

1.	epithelium-derived relaxant factor
2.	Ozone
3.	Lipopolysaccharides