theaflavin

Catechin dimer joined at B rings

Also Known As:

1,8-bis((2R,3R)-3,5,7-trihydroxy-2H-1-benzopyran-2-yl)-3,4,6-trihydroxy-5H-benzocyclohepten-5-one; 1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5H-benzocyclohepten-5-one; theaflavine

Networked: 78 relevant articles (12 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ho, Chi-Tang: 5 articles (06/2015 - 01/2002)
2.	Tu, Youying: 4 articles (03/2022 - 02/2016)
3.	Takemoto, Masumi: 4 articles (04/2018 - 01/2012)
4.	Takemoto, Hiroaki: 3 articles (04/2018 - 08/2016)
5.	Chen, Yi Charlie: 3 articles (11/2017 - 02/2016)
6.	Rankin, Gary O: 3 articles (11/2017 - 02/2016)
7.	Roy, Anup: 3 articles (01/2016 - 05/2009)
8.	Meng, Shijie: 2 articles (01/2021 - 01/2020)
9.	Shan, Letian: 2 articles (01/2021 - 01/2020)
10.	Yan, Bo: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Reperfusion Injury 02/01/2021 - "Theaflavin ameliorates renal ischemia/reperfusion injury by activating the Nrf2 signalling pathway in vivo and in vitro." 01/01/2019 - "Theaflavin 3,3'-digallate (TF3), is reported to protect cardiomyocytes from lipotoxicity and reperfusion injury. " 01/01/2006 - "Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1." 12/01/2019 - "Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress." 01/06/2012 - "Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model."
2.	Carcinogenesis 03/01/2006 - "Among these black tea components, theaflavin is generally considered to be the more effective component for the inhibition of carcinogenesis. " 01/01/2016 - "The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any. " 01/01/2016 - "The aim of this study is to evaluate chemopreventive and therapeutic efficacy of tea polyphenols epigallocatechin gallete (EGCG) and theaflavin (TF) on self-renewal Wnt and Hedgehog (Hh) pathways during CCl4/N-nitosodiethylamine-induced mouse liver carcinogenesis. " 08/01/2006 - "In the present study, the protective activity of diallylsulfide and lycopene and theaflavin, important antioxidative ingredients of garlic, tomato and black tea, respectively, was assessed during colon carcinogenesis. " 01/01/2016 - "Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways."
3.	Infections 04/18/2023 - "Theaflavin Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo." 09/28/2013 - "Theaflavin:epicatechin combinations show real potential for future use as a treatment for infections caused by C. " 01/01/2022 - "In this molecular docking study, we found that theaflavin (TF) preferentially binds the allosteric site of penicillin-binding protein 2a (PBP2a), inducing the PBP2a active site to open, which is convenient for β-lactam antibiotics to treat MRSA infection, instead of directly exerting antibacterial activity at the active site. "
4.	Brain Ischemia (Cerebral Ischemia) 01/01/2006 - "Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1." 01/01/2006 - "The purpose of this study was to verify whether theaflavin reduces focal cerebral ischemia injury in a rat model of middle cerebral artery occlusion (MCAO). " 12/01/2019 - "Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress." 01/01/2007 - "Modulation of the oxidative stress and nuclear factor kappaB activation by theaflavin 3,3'-gallate in the rats exposed to cerebral ischemia-reperfusion." 01/01/2006 - "Our study demonstrated that theaflavin significantly protected neurons from cerebral ischemia-reperfusion injury by limiting leukocyte infiltration and expression of ICAM-1, and suppressing upregulation of inflammatory-related prooxidative enzymes (iNOS and COX-2) in ischemic brain via, at least in part, reducing the phosphorylation of STAT-1."
5.	Fibrosis (Cirrhosis) 06/01/2015 - "The objective of this study was to investigate the protective effects of theaflavin-enriched black tea extracts (TF-BTE) on hepatic fibrosis induced by dimethylnitrosamine (DMN) administration in Sprague-Dawley (SD) rats. "

Related Drugs and Biologics

1.	Tea
2.	Polyphenols
3.	theaflavin-3,3'-digallate
4.	Dimethylnitrosamine (Nitrosodimethylamine)
5.	Lycopene
6.	gallocatechol (epigallocatechin)
7.	allyl sulfide
8.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
9.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
10.	Cyclooxygenase 2 (Cyclooxygenase-2)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Fat-Restricted Diet (Diet, Fat Restricted)