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10-formyldihydrofolate
methotrexate metabolite; inhibits thymidylate synthetase and glycinamide ribotide transformylase
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Pteridines: 147
Pterins: 160
Folic Acid: 19425
10-formyldihydrofolate: 2
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
01/01/1991 - "
The concentrations of 10-formyltetrahydrofolate and 10-formyldihydrofolate were measured in dividing hepatoma cells by a novel enzymatic assay and were found to be 5 microM and undetectable, respectively.
"
2.
Breast Neoplasms (Breast Cancer)
05/25/1988 - "
The folate compound 10-formyldihydrofolate (H2folate) has not been found as a component of intracellular folates in normal tissues but has been identified in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells.
"
Related Drugs and Biologics
1.
Methotrexate (Mexate)
2.
Folic Acid (Vitamin M)
3.
10-formyltetrahydropteroylglutamic acid