tafenoquine

Also Known As:

(R)-tafenoquine succinate; Arakoda; Krintafel; N(4)-(2,6-dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine; SB-252263-AX; SB-252263AX; SB252263-AX; SB252263AX; WR 238605; WR-238605; WR238605; butanedioic acid, compd. with N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (1:1); butanedioic acid, compd. with N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (1:1), (R)-; tafenoquine maleate; tafenoquine succinate; tafenoquine succinate, (R)-

Networked: 173 relevant articles (30 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        tafenoquine: 173

Experts

1.	Duparc, Stephan: 16 articles (01/2022 - 12/2013)
2.	Green, Justin A: 14 articles (01/2022 - 03/2014)
3.	Mohamed, Khadeeja: 9 articles (01/2022 - 09/2014)
4.	Llanos-Cuentas, Alejandro: 8 articles (05/2022 - 03/2014)
5.	Smith, Bryan: 8 articles (01/2022 - 02/2014)
6.	Chu, Cindy S: 8 articles (03/2021 - 01/2017)
7.	Koh, Gavin C K W: 8 articles (01/2020 - 02/2016)
8.	Bancone, Germana: 8 articles (01/2019 - 01/2017)
9.	Edstein, Michael D: 7 articles (06/2022 - 12/2003)
10.	Baird, J Kevin: 7 articles (01/2021 - 03/2003)

Related Diseases

1.	Malaria 02/01/2010 - "Although the volunteers' precise exposure to malaria could not be proven in this study, tafenoquine appears to be a highly efficacious drug for malaria prophylaxis." 05/01/2007 - "In well-designed studies, tafenoquine was highly effective in both the radical cure of relapsing malaria and causal prophylaxis of Plasmodium vivax and P. " 07/07/2021 - "In this meta-analysis, we examined if a loading dose of tafenoquine alone is effective in preventing malaria in short-term travellers. " 10/15/2004 - "vivax occurred in placebo recipients, giving tafenoquine a protective efficacy of 97% for all malaria (95% confidence interval [CI], 82%-99%), 96% for P. " 01/01/2022 - "Efficacy of tafenoquine in the prophylaxis and treatment of malaria by Plasmodium vivax, systematic review and meta-analysis"
2.	Infections 01/01/2022 - "Tafenoquine is a highly effective treatment for Babesia microti infections in animal models. " 04/01/2003 - "Treatment with WR 238605 at a dose of 3.16 mg(base)/kg/day x 7 days cured established trophozoite induced infections in monkeys with both these parasites. " 01/01/2022 - "Tafenoquine was recently approved as a prophylaxis and radical cure for Plasmodium vivax infection, but its Plasmodium falciparum transmission-blocking efficacy is unclear. " 05/01/1997 - "A total dose of 9 mg/kg of WR 238605 over a three-day period cured all three monkeys of their infections. " 08/31/2023 - "Two days post-infection, mice were treated with 20 mg/kg of tafenoquine succinate or vehicle control administered orally by gavage. "
3.	Parasitemia 05/01/1997 - "A total dose of 3 mg/kg of WR 238605 given at a dosage of 1 mg/kg/day for three days cleared patent parasites in all eight monkeys but recrudescence of parasitemia occurred 15-25 days after initiation of treatment. " 08/31/2023 - "Consistent with previous studies, a single oral dose of 20 mg/kg tafenoquine resulted in a rapid reduction in parasitemia. " 08/31/2023 - "Previous studies of mice infected with Babesia microti have shown that a single dose of tafenoquine administered orally is extremely effective at decreasing microscopically detectable parasitemia. " 08/31/2023 - "This allowed us to correlate blood plasma levels of tafenoquine with reductions in parasitemia in treated mice. " 08/31/2023 - "Parasitemia and plasma levels of tafenoquine were evaluated every 24 h post-treatment for 96 h. "
4.	Vivax Malaria 01/01/2021 - "Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives." 01/01/2022 - "Se utilizó la sintaxis ((Malaria Vivax) AND (tafenoquine) AND (prophylaxis)) OR [(Malaria Vivax) AND (tafenoquine) AND (relapse)] en las siguientes bases de datos: Pubmed, The Cochrane Central Register of Controlled Clinical Trials (CENTRAL), ISIS Web of Science, Lilacs y Scopus. " 01/01/2022 - "Materials and methods: We established the MeSH and DeCS descriptors and we used the syntax ((Malaria Vivax) AND (tafenoquine) AND (prophylaxis)) OR [(Malaria Vivax) AND (tafenoquine) AND (relapse)] in the following databases: Pubmed, The Cochrane Central Register of Controlled Clinical Trials (CENTRAL), ISIS Web of Science, Lilacs, and Scopus. " 01/01/2019 - "Clinical utility of tafenoquine in the prevention of relapse of Plasmodium vivax malaria: a review on the mode of action and emerging trial data." 01/01/2017 - "A randomized, double-blind, active-control trial to evaluate the efficacy and safety of a three day course of tafenoquine monotherapy for the treatment of Plasmodium vivax malaria."
5.	Glucosephosphate Dehydrogenase Deficiency 12/28/2016 - "vivax Clinical trials of tafenoquine in Peru have been promising, and glucose-6-phosphate dehydrogenase deficiency in the region has not been observed to be a limitation to its use. " 01/01/2020 - "Letter to the editor: G6PD deficiency in the Tafenoquine era." 06/01/2019 - "Testing for G6PD deficiency is mandatory before tafenoquine prescription. " 11/04/2016 - "Tafenoquine, the only new anti-relapse scaffold for patients with a glucose-6-phosphate dehydrogenase deficiency, has raised significant concerns due to its hemolytic activity. " 04/29/2015 - "Adverse effects of tafenoquine are assessed in populations where people with G6PD deficiency have been excluded, and in populations without screening for G6PD deficiency. "

Related Drugs and Biologics

1.	Primaquine
2.	tafenoquine
3.	Mefloquine (Lariam)
4.	Antimalarials (Antimalarial Agents)
5.	Chloroquine (Aralen)
6.	Artesunate
7.	8-aminoquinoline
8.	Enzymes
9.	Succinic Acid (Succinate)
10.	quinoline

Related Therapies and Procedures

1.	Chemoprevention
2.	Secondary Prevention
3.	Therapeutics
4.	Drug-Eluting Stents
5.	Stents