columbamine

12/17/2012 - "In this study, we explored novel small molecular anti-metastatic osteosarcoma agents and found that columbamine (COL), an active component of the herb Coptis chinensis, inhibited the proliferation and neovascularization of metastatic osteosarcoma U2OS cells. "
01/01/2019 - "Columbamine has been identified as an effective anti-osteosarcoma compound with only minor side effects. "
12/17/2012 - "Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity."

01/01/2019 - "Columbamine significantly inhibited the proliferation, migration, invasion process of colon cancer cells, and dramatically promoted the apoptosis rate of colon cancer cells to further suppress the development of colon cancer to tumor. "
01/01/2019 - "The present study indicated that columbamine exerts its anti-tumor effect in colon cancer cells through abolishing Wnt/β-catenin signaling pathway. "

02/01/2021 - "The goal of this study is to explore the effects of columbamine in melanoma cells and the signaling pathway involved. "
02/01/2021 - "Columbamine inhibited melanoma cell proliferation, migration, and invasion in A375 cells through inactivation of STAT3, which is mediated by HSP90."
02/01/2021 - "Columbamine suppresses proliferation and invasion of melanoma cell A375 via HSP90-mediated STAT3 activation."

01/01/2019 - "In this study, we analyzed the anticancer effect of columbamine on colon cancer. "
01/01/2019 - "MTT assay, colony formation assay, apoptosis detection and tumorigenicity assay were performed to detect the protective effect of columbamine on colon cancer development. "
01/01/2019 - "Human colon cancer cell lines were treatment with columbamine. "
01/01/2019 - "Columbamine may be a new therapy compound for colon cancer."
01/01/2019 - "Columbamine significantly inhibited the proliferation, migration, invasion process of colon cancer cells, and dramatically promoted the apoptosis rate of colon cancer cells to further suppress the development of colon cancer to tumor. "

01/01/2021 - "Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma [Retraction]."
01/01/2021 - "Columbamine inhibits proliferation, migration, invasion, and induces apoptosis in glioma cell lines (SHG44 and U251). "
01/01/2021 - "Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma."
01/01/2021 - "In this research, we find that columbamine could inhibit proliferation and metastasis of glioma cell lines, and promote apoptosis of glioma cell lines via regulating PTEN/AKT signal pathway. "
01/01/2021 - "PTEN inhibitor (SF1670) and AKT activator (SC79) were used to explore the mechanism of columbamine on glioma cell progression. "