vatinoxan

structure given in first source

Also Known As:

L 659066; L-659,066; MK 467; MK-467; Methanesulfonamide, N-(2-(1,3,4,6,7,12b-hexahydro-2'-oxospiro(2H-benzofuro(2,3-a)quinolizine-2,4'-imidazolidin)-3'-yl)ethyl)-, trans-; vatinoxan hydrochloride

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolizines: 1
      - vatinoxan: 23

Experts

1.	Honkavaara, Juhana: 6 articles (09/2020 - 01/2017)
2.	Vainio, Outi M: 6 articles (04/2018 - 09/2008)
3.	Raekallio, Marja: 5 articles (01/2022 - 03/2018)
4.	Raekallio, Marja R: 5 articles (04/2018 - 09/2008)
5.	Scheinin, Mika: 4 articles (09/2020 - 05/2013)
6.	Pypendop, Bruno H: 3 articles (01/2022 - 01/2017)
7.	Auer, Ulrike: 2 articles (01/2022 - 07/2020)
8.	Einwaller, Joy: 2 articles (01/2022 - 07/2020)
9.	Painer, Johanna: 2 articles (01/2022 - 07/2020)
10.	Hautajärvi, Heidi: 2 articles (09/2020 - 04/2018)

Related Diseases

1.	Bradycardia 10/01/2018 - "It was hypothesised that MK-467 would alleviate bradycardia, hasten drug absorption and thus intensify the early-stage sedation. " 01/01/2017 - "To determine a dose of MK-467, a peripheral α2-adrenoceptor antagonist, which, when administered intravenously (IV) concomitantly with 25 μg kg-1 of dexmedetomidine, will prevent bradycardia without altering sedation in cats. " 05/01/2013 - "MK-467 prevented detomidine induced bradycardia and intestinal hypomotility. " 09/01/2008 - "The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs." 01/01/2017 - "The effect of MK-467, a peripheral α2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia after intravenous administration in conscious cats."
2.	Hypotension (Low Blood Pressure) 07/01/2018 - "Following administration of the 30- and 60-μg/kg doses of MK-467, all cats developed clinical hypotension (mean arterial pressure, < 60 mm Hg) even though CI and SVR returned to baseline values. " 03/01/2018 - "Alpha-2-agonist induced vasoconstriction was reversed by the MK-467 dose used, resulting in hypotension and rise in CI. " 09/01/2020 - "However, vatinoxan was associated with mild hypotension after ketamine with the dose used in this study. " 11/01/2019 - "Vatinoxan resulted in severe hypotension at target plasma dexmedetomidine concentrations <10 ng mL-1. " 07/01/2020 - "Vatinoxan reversed hypertension and bradycardia induced by medetomidine without causing hypotension or affecting the level of anaesthesia in red deer. "
3.	Hypertension (High Blood Pressure) 01/01/2022 - "Vatinoxan significantly reduced systemic and pulmonary artery hypertension, induced by medetomidine in wild boar." 01/01/2019 - "In general, vatinoxan alleviated the hypertension induced by medetomidine without affecting the quality of immobilization. " 08/01/2017 - "RESULTS The characteristic cardiovascular effects of medetomidine, such as bradycardia, hypertension, and reduction in cardiac index, were obtunded by MK-467. " 07/01/2017 - "Dexmedetomidine induced bradycardia and hypertension, which were attenuated by all three doses of MK-467. " 07/01/2020 - "Vatinoxan reversed hypertension and bradycardia induced by medetomidine without causing hypotension or affecting the level of anaesthesia in red deer. "
4.	Hypoxia (Hypoxemia) 01/01/2019 - "In this study, the hypothesis was that vatinoxan would dose-dependently alleviate medetomidineinduced bradycardia, hypertension, and hypoxemia when administered intravenously (IV) after medetomidine and ketamine were administered intramuscularly (IM) to markhors (Capra falconeri heptneri), without impairing the immobilization. "
5.	Stroke (Strokes) 01/01/2017 - "Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index. "

Related Drugs and Biologics

1.	Ketamine
2.	Medetomidine
3.	Dexmedetomidine
4.	Yohimbine (Yocon)
5.	Phenylephrine (Neo-Synephrine)
6.	Norepinephrine (Noradrenaline)
7.	Isoflurane
8.	detomidine
9.	Imidazolines
10.	Growth Hormone (Somatotropin)

Related Therapies and Procedures

1.	Intravenous Administration