HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

phenyl- (2- difluoroethyl)- 4- aminopropylamidinohydrazone (DFPA)

structure given in first source

Also Known As:

DFPA; difluorophenylethyl(4-aminopropylamidinohydrazone)

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone: 3
- Hydrazines: 379
  - Hydrazones: 500
    - phenyl-(2-difluoroethyl)-4-aminopropylamidinohydrazone: 3

Related Diseases

1.	Thrombosis (Thrombus) 08/15/1989 - "Finally, due to its cross-reactivity with dFPA, assays using this antibody should also be valuable in the canine experimental thrombosis model studies."
2.	Neoplasms (Cancer) 01/01/1991 - "[18F]DFPA proved of value to image and circumscribe intracerebral tumors in awake rats, and studies are continuing to facilitate its clinical application in brain tumor patients." 01/01/1991 - "Male Fischer 344 rats were intracerebrally implanted with Walker 256 carcinosarcoma tumor cells (1 x 10(6) in 5 microliters tissue culture media) and 7 days later were infused with [18F]DFPA (500-1000 mCi/mmol) i.v. for 5 min. Rats were killed after 20 min. Brains were removed and either prepared for autoradiography, or brain and tumor were separated and their radioactivity quantified by gamma spectroscopy. "
3.	Brain Neoplasms (Brain Tumor) 01/01/1991 - "Positron emitting dl-erythro-9,10[18F]difluoropalmitate, [18F]DFPA, was synthesized for the in vivo imaging of brain tumors in rats. " 01/01/1991 - "[18F]DFPA proved of value to image and circumscribe intracerebral tumors in awake rats, and studies are continuing to facilitate its clinical application in brain tumor patients."
4.	Leukemia 03/01/1988 - "Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. "
5.	Carcinosarcoma 01/01/1991 - "Male Fischer 344 rats were intracerebrally implanted with Walker 256 carcinosarcoma tumor cells (1 x 10(6) in 5 microliters tissue culture media) and 7 days later were infused with [18F]DFPA (500-1000 mCi/mmol) i.v. for 5 min. Rats were killed after 20 min. Brains were removed and either prepared for autoradiography, or brain and tumor were separated and their radioactivity quantified by gamma spectroscopy. "

Related Drugs and Biologics

1.	S-Adenosylmethionine (Ademetionine)
2.	Ornithine
3.	Culture Media
4.	Carboxy-Lyases