hepsin

10/23/2023 - "The study demonstrates a role for hepsin as a regulator of cell proliferation and tumor growth through TGFβ and EGFR pathways, warranting consideration of hepsin as a potential indirect upstream target for therapeutic inhibition of TGFβ and EGFR pathways in cancer."
10/23/2023 - "However, how exactly active hepsin promotes cell proliferation machinery to sustain tumor growth is not fully understood. "
01/01/2023 - "Discussion: Our results demonstrate that hepsin overexpression correlates with a more aggressive and prothrombotic tumor phenotype. "
06/24/2022 - "Among metastatic patients, low hepsin expression was associated with a low degree of tumor differentiation (p-value < 0.001) and with major metastatic dissemination (p-value = 0.023). "
06/24/2022 - "In localized cancer patients, high-intensity hepsin staining was associated with reduced 5-year disease-free survival (p-value = 0.16). "

10/01/2017 - "The importance of hepsin in prostate cancer has been demonstrated by several studies. "
01/01/2022 - "Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer."
10/08/2020 - "In addition, we identified another marker gene, Hepsin (HPN), with a 0.930 area under the curve score distinguishing normal tissue from prostate cancer lesion. "
02/12/2020 - "Correction: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells."
01/01/2020 - "Hepsin promotes EMT and cell invasion through the miR-222/PPP2R2A/AKT axis in prostate cancer."

04/01/2007 - "There was a trend of higher hepsin expression in RCC with distant metastasis, and Kaplan-Meier survival curves showed that high hepsin expression was associated with reduced overall survival (P<0.01, log-rank test). "
06/24/2022 - "Consequently, we aimed to study the correlations between hepsin expression and different clinical-histopathological variables in 169 patients with localized colorectal cancer and 118 with metastases. "
01/01/2022 - "Moreover, genomic amplifications of hepsin, not deletions or other alterations, were significantly associated with prostate cancer metastasis. "
12/01/2018 - "Taken together, our data reveal a critical CtsD-hepsin signaling axis in migration and metastasis, which may contribute to a better understanding of the function and molecular mechanism in breast cancer progression."
01/01/2017 - "Hepsin is highly expressed in prostate cancer (PCa) and associated with its progression and metastasis. "

01/01/2020 - "In db/db mice, hepsin deficiency ameliorates obesity and diabetes. "
01/01/2020 - "These data indicate that hepsin is a key regulator in liver metabolism and energy homeostasis, suggesting that hepsin could be a therapeutic target for treating obesity and diabetes."
06/23/2023 - "In mice, hepsin deficiency increases adipose browning and protects from high-fat diet-induced hyperglycemia, hyperlipidemia, and obesity. "
01/01/2020 - "Hepsin-deficient mice exhibit marked resistance to high-fat diet-induced obesity, hyperglycemia, and hyperlipidemia. "

01/01/2018 - "Subsequent in vitro ADMET profiling and cellular studies confirmed that the leading compounds are useful tools for interrogating the role of hepsin in breast tumorigenesis."
11/22/2004 - "The 10 most frequently selected genes, include hepsin, GSTP1 and AMACR, which have recently been proposed to be associated with prostate carcinogenesis. "
09/01/2006 - "Hepsin is a type II transmembrane protein predominantly expressed in the liver and has been implicated in participation in blood coagulation pathway and epithelial carcinogenesis. "
08/15/2005 - "Together, our findings suggest that the HGF precursor is a potential in vivo substrate for hepsin in tumours, where hepsin expression is dysregulated and may influence tumorigenesis through inappropriate activation and/or regulation of HGF receptor (c-Met) functions."
06/01/2008 - "Based on studies with the related proteins matriptase and hepsin, TMPRSS2 should be investigated for causal roles in prostate carcinogenesis."