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isoimperatorin

tumor necrosis factor antagonist isolated from Glehniae root

Also Known As:

iso-imperatorin; 7H-furo(3,2-g)(1)benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)-

Networked: 24 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        isoimperatorin: 24
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        isoimperatorin: 24
  - 3-Ring Heterocyclic Compounds
    - Furocoumarins: 490
      - isoimperatorin: 24

Experts

1.	Wang, Nan: 2 articles (11/2020 - 04/2014)
2.	Seo, Chang-Seob: 2 articles (08/2017 - 02/2005)
3.	Alkhodairy, Salman F: 1 article (02/2022)
4.	Alotaibi, Abdullah D: 1 article (02/2022)
5.	Anwar, Sadaf: 1 article (02/2022)
6.	Arif, Jamal M: 1 article (02/2022)
7.	Kausar, Mohd Adnan: 1 article (02/2022)
8.	Khalifa, Amany Mohammed: 1 article (02/2022)
9.	Khan, Mohammad Kalim Ahmad: 1 article (02/2022)
10.	Khatoon, Fahmida: 1 article (02/2022)

Related Diseases

1.	Osteoarthritis 12/01/2017 - "Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin C1 signaling pathway."
2.	Neoplasms (Cancer) 01/01/2017 - "Additionally, a xenograft assay was used to confirm whether isoimperatorin had an inhibitory effect on SGC-7901 cell-induced tumors in vivo. " 11/01/2022 - "Here, we have investigated whether Isoimperatorin (IIPT), derived from Angelica dahurica can modulate CXCR4 signaling axis-related epithelial-to-mesenchymal transition (EMT) and tumor metastasis process. " 05/01/2018 - "Isoimperatorin (ISOIM), a coumarin compound, exhibits antitumor functions in multiple types of tumor cells. " 01/06/2021 - "Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. " 01/01/2022 - "Finally, we found that four natural compounds (dihydrotanshinone, sclareol, isoimperatorin, and girinimbin) have recently attracted the most attention in the field of anti-cancer research. "
3.	Pain (Aches) 01/01/2022 - "In contrast, isoimperatorin and pregnenolone did not relieve CFA-induced inflammatory pain. " 04/06/2021 - "In this study, five monomers from Bupleurum chinense (Saikosaponin A, Saikosaponin B1, Saikosaponin B2, Saikosaponin C, Saikosaponin D) and five monomers from the Angelica biserrata (Osthole, Xanthotoxin, Imperatorin, Isoimperatorin, Psoralen) were examined by whole-cell patch-clamp on Nav1.7, which was closely associated with pain. "
4.	Melanoma (Melanoma, Malignant) 10/02/2022 - "The present study investigated the melanogenic effects of imperatorin and isoimperatorin and the underlying mechanisms of imperatorin using a mouse melanoma B16F10 model. "
5.	Inflammation (Inflammations) 11/01/2020 - "Isoimperatorin (ISO), an active natural furocoumarin, possesses multiple pharmacological properties, including an anti-inflammation effect. " 08/01/2017 - "Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma."

Related Drugs and Biologics

1.	TOR Serine-Threonine Kinases
2.	imperatorin
3.	Ficusin (Psoralen)
4.	Silicon Dioxide (Silica)
5.	Methoxsalen (Oxsoralen)
6.	osthol (osthole)
7.	saikosaponin D
8.	Furocoumarins (Furanocoumarins)
9.	oxypeucadanin
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Ligation
3.	Oral Administration