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conotoxin GV

NMDA antagonist from Conus geographus

Also Known As:

CGX-1007; conantokin-G; conotoxin G V; sleeper peptide; snail sleeper peptide

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Mollusk Venoms: 21
    - Conotoxins: 172
      - conotoxin GV: 11
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Mollusk Venoms: 21
      - Conotoxins: 172
        conotoxin GV: 11
  - Marine Toxins: 124
    - Mollusk Venoms: 21
      - Conotoxins: 172
        conotoxin GV: 11

Experts

1.	Tortella, Frank C: 2 articles (09/2005 - 05/2002)
2.	Williams, Anthony J: 2 articles (09/2005 - 05/2002)
3.	Barton, Matthew E: 2 articles (03/2004 - 03/2004)
4.	White, H Steve: 2 articles (03/2004 - 03/2004)
5.	Dave, J R: 2 articles (11/2003 - 07/2000)
6.	Tortella, F C: 2 articles (11/2003 - 07/2000)
7.	Williams, A J: 2 articles (11/2003 - 07/2000)
8.	Dhiman, Varun: 1 article (05/2021)
9.	Pant, Deepak: 1 article (05/2021)
10.	Chang, Hang-Seok: 1 article (07/2019)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 11/01/2003 - "In conclusion, CGX-1007 effectively attenuated gene expression associated with delayed cell death as related to a neuroprotective relief of cerebral ischemia." 05/07/2002 - "Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia." 07/01/2000 - "Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies." 09/21/2005 - "The potent NMDA receptor antagonist, Conantokin-G (CGX-1007), a snail peptide, has an 8-h therapeutic window in rat focal cerebral ischemia. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/07/2002 - "Using the same model of middle cerebral artery occlusion (MCAo) in rats we now report the neuroprotective effects of CGX-1007 when delivered intrathecally (i.t.). " 11/01/2003 - "In this study we have evaluated the upregulation of several genes associated with delayed cell death (c-fos, bax, and bcl-2) during the initial 24 h of transient middle cerebral artery occlusion (MCAo) in the rat and the effects of postinjury treatment with the NR2B subunit specific NMDA receptor antagonist CGX-1007 (Conantokin-G, Con-G). "
3.	Seizures (Absence Seizure) 03/01/2004 - "The present study was designed to assess the effects of CGX-1007 and CI-1041 on the acquisition and expression of kindled seizures. " 03/01/2004 - "Although both CI-1041 and CGX-1007 are reportedly NR2B specific antagonists, they differ in their ability to block amygdala-kindled seizures, suggesting that the mechanism of action of these compounds differs. " 03/01/2004 - "In the corneal kindled rat, CGX-1007 [Epilepsia 36 (1998) 39] and CI-1041, administered p.o., 2h prior to the kindling stimulation displayed time- and dose-dependent block of fully expressed corneal kindled seizures (ED50 = 300 pmol and 2.5mg/kg for CGX-1007 and CI-1041, respectively). "
4.	Brain Injuries (Brain Injury) 11/01/2003 - "Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats." 01/01/2015 - "The neuroprotective activity of conantokin-G (con-G), a naturally occurring antagonist of N-methyl-D-aspartate receptors (NMDAR), was neurologically and histologically compared in the core and peri-infarct regions after ischemia/reperfusion brain injury in male Sprague-Dawley rats. " 05/07/2002 - "The NMDA antagonist CGX-1007 (Conantokin-G) has previously been shown to possess potent neuroprotective properties when administered intracranially following experimental ischemic brain injury. "
5.	Pain (Aches) 02/01/2009 - "In a model of neuropathic spinal cord injury pain, which is clinically difficult to treat, the combination of conantokin-G and omega-conotoxin MVIIA resulted in robust synergistic antinociception. " 02/01/2009 - "Antinociceptive effects of the marine snail peptides conantokin-G and conotoxin MVIIA alone and in combination in rat models of pain." 01/01/2012 - "Conantokin G (CTG), isolated from the venom of the marine cone snail Conus geographus, is an antagonist of N-methyl-d-aspartate receptors (NMDARs), the activation of which, especially those located on the central afferent terminals and dorsal horn neurons, leads to hypersensitivity and pain. "

Related Drugs and Biologics

1.	conotoxin GV
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	N-Methylaspartate (NMDA)
4.	besonprodil
5.	Peptides (Polypeptides)
6.	Conotoxins (Conotoxin)
7.	Neuroprotective Agents
8.	Venoms
9.	Amantadine (Aman)
10.	Xen2174