methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

bifunctional enzyme which contains Mg-NAD dependent covalently linked methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); usually found in prokaryotes

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Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Neoplasms (Cancer) 04/05/1988 - "The activities of the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells are kinetically independent." 07/15/1986 - "NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. " 04/05/1988 - "The bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells has very different kinetic properties from the larger NADP-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase present in all mammalian cells. "
2.	Ascites 04/05/1988 - "The activities of the NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells are kinetically independent." 07/15/1986 - "NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. " 04/05/1988 - "The bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells has very different kinetic properties from the larger NADP-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase present in all mammalian cells. "
3.	Thrombosis (Thrombus) 06/01/1998 - "We identified 12 up-regulated distinct genes including 5 cell growth-related genes (two phosphatases CL100 and B23/hVH-3, gravin, activating transcription factor-4, and heparin-binding epidermal growth factor-like growth factor), 3 thrombosis-related genes (plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombomodulin), and 4 others (stanniocalcin, NAD-dependent methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, BENE, and reducing agents and tunicamycin-responsive protein). "

Related Drugs and Biologics

1.	Activating Transcription Factor 4
2.	Methenyltetrahydrofolate Cyclohydrolase
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Reducing Agents
5.	Thrombomodulin
6.	Plasminogen Activator Inhibitor 1
7.	Tunicamycin
8.	Proteins (Proteins, Gene)
9.	Tissue Plasminogen Activator (Alteplase)
10.	Phosphoric Monoester Hydrolases (Phosphatases)