BW-A 575C

BW B385C is the isomer with (S)-configurations at all chiral centers

Also Known As:

BW A-575C; BW A575C; BW B385C; BW-B385C; N-(1-carboxy-5-(4-(2-hydroxy-3-isopropylaminopropoxy)-1H-indole-2-carboxamido)pentyl)alanylproline; N-(1-carboxy-5-(4-(3-isopropylamino-2-hydroxypropoxy)indole-2-carboxamido)pentyl)-alanyl-proline

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 03/01/1987 - "Intravenous administration of BW A575C (1-100 micrograms kg-1 min-1) to the pithed rat inhibited in a dose-dependent fashion both angiotensin I-induced pressor responses and isoprenaline-induced tachycardia. " 01/01/1987 - "In conscious instrumented normotensive rats and dogs, intravenous and oral administration of BW A575C causes a dose-dependent rightward displacement of the pressor dose-response curve to angiotensin I (dose ratio of 29.5 and 16.1 in rats and dogs, respectively, at 1.0 mg/kg i.v.) and the tachycardia dose-response curve to isoprenaline (dose ratio of 3.1 and 8.0 in rats and dogs, respectively, at 1.0 mg/kg i.v.). "
2.	Hypertension (High Blood Pressure) 01/01/1987 - "These results confirm the novel pharmacological profile of BW A575C in vivo and demonstrate that this compound is an effective antihypertensive agent in a renin-dependent model of hypertension."

Related Drugs and Biologics

1.	Isoproterenol (Isoprenaline)
2.	Angiotensin I
3.	Renin
4.	Antihypertensive Agents (Antihypertensives)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Oral Administration