zolantidine

structure given in first source

Also Known As:

2-(3-(3-(piperidinomethyl)phenoxy)propylamino)benzothiazole; SK&F 95282; SK&F-95282; SKF 95282; SKF-95282; 2-Benzothiazolamine, N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sadek, Bassem: 3 articles (01/2017 - 01/2016)
2.	Darras, Fouad H: 2 articles (10/2016 - 01/2016)
3.	Decker, Michael: 2 articles (10/2016 - 01/2016)
4.	Khan, Nadia: 2 articles (10/2016 - 01/2016)
5.	Alachkar, Alaa: 1 article (01/2017)
6.	Kieć-Kononowicz, Katarzyna: 1 article (01/2017)
7.	Łażewska, Dorota: 1 article (01/2017)
8.	Pockes, Steffen: 1 article (10/2016)
9.	Nurulain, Syed M: 1 article (01/2016)
10.	Saad, Ali: 1 article (01/2016)

Related Diseases

1.	Pain (Aches) 10/17/2005 - "The present results are the first to demonstrate the existence of brain-penetrating antinociceptive agents chemically related to zolantidine and improgan, but further studies are needed to understand the mechanisms of both the pain relief and toxicity produced by these agents." 12/01/2014 - "Zolantidine or pyrilamine alone in the LC failed to influence pain behavior, while A-960656 (histamine H3 receptor antagonist) suppressed hypersensitivity. "
2.	Hyperphagia (Overeating) 02/01/1992 - "The present study determined the effects of the brain-penetrating H2 receptor antagonist zolantidine (ZOL) on 2DG antinociception on the tail-flick and jump tests, as well as on 2DG hyperphagia, in rats. " 02/01/1992 - "Potentiation of 2-deoxy-D-glucose antinociception, but not hyperphagia by zolantidine, a histamine (H2) receptor antagonist."
3.	Cholestasis 02/01/2011 - "The involvement of histamine H(2) receptors on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis, was investigated in this study using zolantidine and cimetidine as two H(2) receptor antagonists and dimaprit as a selective H(2) receptor agonist. "
4.	Seizures (Absence Seizure) 10/17/2005 - "In addition, loxtidine produced seizures without antinociception, whereas zolantidine produced neither effect after systemic dosing in mice. " 04/01/2002 - "In addition, H2 antagonist zolantidine appeared no appreciable effect, even at a dose of 10 mg/kg. These results indicated that brain endogenous histamine may play certain important role in protect against generalized clonic seizures, its action may via presynaptic H3-receptors and postsynaptic H1-receptors." 05/01/1998 - "H1-antagonists (diphenhydramine and chlorpheniramine) attenuated histidine-induced inhibition of amygdaloid kindled seizures, however no significant antagonism was observed with H2-antagonists (zolantidine and ranitidine). " 10/15/2001 - "H(1)-antagonists (diphenhydramine and chlorpheniramine) attenuated histamine (i.c.v.)-induced inhibition of amygdaloid kindled seizures, however, no significant antagonism was observed with H(2)-antagonists (cimetidine, ranitidine or zolantidine). "
5.	Memory Disorders (Memory Loss) 11/01/1999 - "In contrast, no significant influence on alpha-FMH-induced memory deficit was observed with zolantidine." 01/01/2017 - "Upon acute systemic pretreatment of E159 at three different doses, namely 2.5, 5, and 10 mg/kg, i.p., 2.5 and 5 but not 10 mg/kg of E159 counteracted the DIZ (0.1 mg)-induced memory deficits, and this E159 (2.5 mg)-elicited memory-improving effects in DIZ-induced amnesic model were moderately abrogated after acute systemic administration of scopolamine (SCO), H2R antagonist zolantidine (ZOL), but not with H1R antagonist pyrilamine to the animals. " 10/15/2001 - "On the contrary, the blockade of H(2)-receptors by zolantidine 10 mg/kg reverses both the effect of thioperamide alone and the drug action on the scopolamine-induced memory deficit. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Dimaprit
3.	Cimetidine (Biomet)
4.	Opioid Analgesics (Opioids)
5.	Analgesics (Analgesic Drugs)
6.	SKF 92374
7.	Pyrilamine (Mepyramine)
8.	Chlorpheniramine (Chlorphenamine)
9.	Scopolamine (Hyoscine)
10.	Ranitidine (Zantac)