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trifluoroacetaldehyde

Also Known As:

TFALD; trifluoroacetaldehyde, 1-(2)H-labeled

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - Acetaldehyde: 1345
    - trifluoroacetaldehyde: 1

Related Diseases

1.

Kidney Neoplasms (Kidney Cancer)

11/01/1989 - "The MTX gamma-methyl ester (4) was then converted to the corresponding hydrazide 6. An amide-linked conjugate was formed when the MTX gamma-hydrazide (6) was converted to reactive acylating species 7 by using tert-butyl nitrite or trifluoroacetaldehyde, which were reacted with nucleophilic centers, presumably epsilon-amino groups, in native IgG. A hydrazone-linked conjugate was formed when MTX gamma-hydrazide (6) was reacted directly with IgG that had first been oxidized with periodate to form polyaldehyde IgG. The regiospecifically synthesized conjugates were somewhat more effective inhibitors in vitro of dihydrofolate reductase and of colony formation by human renal cancer (Caki-1) cells than were control nonregiospecific conjugates."

Related Drugs and Biologics

1.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
2.	Immunoglobulin G (IgG)
3.	Hydrazones
4.	Hydrazines
5.	Esters
6.	Amides
7.	n-butyl nitrite (butyl nitrite)
8.	metaperiodate (periodate)