mRNA (guanine(N7))-methyltransferase

catalyzes S-adenosyl-L-methionine and G(5')pppR-RNA to yield S-adenosyl-L-homocysteine and M(7)G(5')pppR-RNA; mRNA containing an N(7)-methylguanine cap; do not confuse with met proto-oncogene protein; RefSeq NM_003799 (human)

Also Known As:

ABD1 protein, S cerevisiae; MET protein, human (Methyltransferase); RG7MT1 protein, human; RNA (guanine-7) methyltransferase; RNA (guanine-7-) methyltransferase protein, human; RNMT protein, human; SPCC330.10 protein, S pombe; YBR236C protein, S cerevisiae; human mRNA cap methyltransferase; mRNA (guanine-7-)methyltransferase; mRNA cap methyltransferase, human; mRNA(guanine-7-)methyltransferase; pcm1 protein, S pombe

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        mRNA (guanine(N7))-methyltransferase: 2

Experts

1.	Baillie, J Kenneth: 1 article (01/2020)
2.	Bukhari, Syed Irfan: 1 article (01/2020)
3.	Chia, Bing Shao: 1 article (01/2020)
4.	Clohisey, Sara M: 1 article (01/2020)
5.	Cui, Ang: 1 article (01/2020)
6.	Digard, Paul: 1 article (01/2020)
7.	Dockrell, David H: 1 article (01/2020)
8.	Doench, John G: 1 article (01/2020)
9.	Eisenhaure, Thomas: 1 article (01/2020)
10.	Farr, David: 1 article (01/2020)

Related Diseases

1.	Vaccinia 12/25/1975 - "Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions."
2.	Human Influenza (Influenza) 01/01/2020 - "We also find that CMTR1, a human mRNA cap methyltransferase, is required for efficient viral cap snatching and regulation of a cell autonomous immune response, and provides synergistic protection with the influenza endonuclease inhibitor Xofluza."

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Endonucleases
3.	mRNA guanylyltransferase
4.	baloxavir