corynoxeine

active principles of Uncariae Ramulus et Uncus; structure given in first source for ((7beta,16E,20alpha)-isomer) and ((16E,20alpha)-isomer); RN given refers to ((7beta,16E,20alpha)-isomer)

Also Known As:

corynoxeine, (16E,20alpha)-isomer; isocorynoxeine; methyl (7beta,16E,20alpha)-17-methoxy-2-oxocorynoxa-16,18-dien-16-carboxylate

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - corynoxeine: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        corynoxeine: 6
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        corynoxeine: 6

Experts

1.	Han, Lifeng: 1 article (11/2021)
2.	Hu, Xiaohan: 1 article (11/2021)
3.	Huang, Wenwen: 1 article (11/2021)
4.	Niu, Lu: 1 article (11/2021)
5.	Pan, Guixiang: 1 article (11/2021)
6.	Teka, Tekleab: 1 article (11/2021)
7.	Wang, Qilong: 1 article (11/2021)
8.	Zhang, Zhonglian: 1 article (11/2021)
9.	He, Jianyu: 1 article (01/2019)
10.	Jahan, Nabila: 1 article (01/2019)

Related Diseases

1.	Ischemia 01/01/2015 - "Isocorynoxeine, one of the major alkaloids from Uncaria Hook, shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. "
2.	Vascular Diseases (Vascular Disease) 05/15/2014 - "Corynoxeine(CX), isolated from the extract of Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. " 11/01/2008 - "These results suggest that corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and restenosis after angioplasty."
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/2019 - "Effects of isocorynoxeine, from Uncaria, on lower urinary tract dysfunction caused by benign prostatic hyperplasia via antagonism of α1A-adrenoceptors."
4.	Hypertension (High Blood Pressure) 11/30/2021 - "Further, the potential vasodilative compounds which include corynoxeine, isocorynoxeine, isorhynchophylline, rhynchophylline, hirsuteine and hirsutine were screened through the correlation analysis between metabolites and anti-hypertension activities. "
5.	Body Weight (Weight, Body) 12/01/2014 - "The concentration-time curves of four prototype compounds, senkyunolide I, ajmalicine, isocorynoxeine and rhynchophylline were constructed after an oral (9.1g YGS per kilogram of body weight) administration in rats. "

Related Drugs and Biologics

1.	Alkaloids
2.	corynoxeine
3.	rhyncophylline
4.	Becaplermin (PDGF-BB)
5.	senkyunolide I
6.	hirsuteine
7.	hirsutine
8.	raubasine (ajmalicine)