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DAB(486)-interleukin 2
portions of diptheria toxin linked to IL-2; causes antigen specific immunosupression
Also Known As:
DAB(486)-IL-2; DAB486-IL-2; interleukin 2 toxin
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Transferases: 6589
Glycosyltransferases: 784
Pentosyltransferases
ADP Ribose Transferases: 198
Diphtheria Toxin: 708
DAB(486)-interleukin 2: 3
Biological Factors: 2472
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
Interleukins: 25257
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Lymphokines: 811
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Biological Toxins: 20
Bacterial Toxins: 814
Diphtheria Toxin: 708
DAB(486)-interleukin 2: 3
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
Interleukins: 25257
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Lymphokines: 811
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Recombinant Proteins: 2754
Recombinant Fusion Proteins: 333
DAB(486)-interleukin 2: 3
Peptides: 82426
Intercellular Signaling Peptides and Proteins: 29768
Cytokines: 164289
Interleukins: 25257
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Lymphokines: 811
Interleukin-2: 17447
DAB(486)-interleukin 2: 3
Related Diseases
1.
Neoplasms (Cancer)
01/01/1995 - "
The results from the phase I/II studies of the intravenous administration of DAB486-IL-2 to patients with refractory haematological malignancies have now proven in principle the feasibility of fusion toxin therapy in man.
"
2.
Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/01/1992 - "
Taken together, these studies strongly support the concept that IL 2R-bearing T cells are essential for the induction of IDDM and suggest that DAB486-IL-2 would be a promising therapeutic approach in the treatment of human IDDM.
"
03/01/1992 - "
We set DAB486-IL-2 the challenging task of preventing fulminant IDDM accelerated by the adoptive transfer of diabetic spleen cells.
"
3.
Diphtheria
11/25/1990 - "
Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.
"
Related Drugs and Biologics
1.
Interleukin-2 (IL2)
Related Therapies and Procedures
1.
Intravenous Administration
2.
Therapeutics