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4- acetylphenyloxooxazolidinylmethylacetamide

structure given in first source; acts on gram+ and anaerobic bacteria

Also Known As:

DuP 721; DuP-721

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxazolidinones: 316
        4-acetylphenyloxooxazolidinylmethylacetamide: 3

Related Diseases

1.	Streptococcal Infections (Streptococcal Infection) 11/01/1987 - "DuP 721 and DuP 105 administered by either the oral or the parenteral route were protective against staphylococcal and streptococcal infections in mice. "
2.	Tuberculosis (Tuberculoses) 11/01/1991 - "tuberculosis, the 50% effective dose (ED50) for DuP-721 was 13.2 mg/kg when administered daily beginning 4 hr postinfection for 17 days. " 11/01/1991 - "tuberculosis as indicated by the liquid scintillation radiometric method was 56% at fourfold the minimum inhibitory concentration (MIC) of DuP-721 that compared well to that of the fourfold MIC concentrations of rifampicin and isoniazid. " 02/01/1993 - "tuberculosis was comparable to those of isoniazid and rifampin, it was superior to those of streptomycin, ciprofloxacin or norfloxacin, and oxazolidinone DuP 721. "
3.	Infections 11/01/1991 - "A 100% survival rate was obtained at 50 and 160 mg/kg when DuP-721 was administered daily for 17 days, and only on days 11 and 12 after the infection, respectively. " 11/01/1991 - "The increase in the survival time by DuP-721 at 100 mg/kg (eightfold the ED50 dose) when administered daily for 17 days beginning 4 hr after infection was inferior to that by eightfold the ED50 dose of rifampicin and isoniazid administered on days 11 and 12 postinfection.(ABSTRACT TRUNCATED AT 250 WORDS)"

Related Drugs and Biologics

1.	4- methylsulfinylphenyloxooxazolidinylmethylacetamide
2.	Rifampin (Rifampicin)
3.	Isoniazid (Ftivazide)
4.	Oxazolidinones (2 Oxazolidone)
5.	Streptomycin (Streptomycin Sulfate)
6.	Norfloxacin
7.	Ciprofloxacin (Cipro)