ADN 138

structure given in first source

Also Known As:

8'-chloro-2',3'-dihydrospiro(pyrrolidine-3,6'(5'H)-pyrrolo(1,2,3-de)(1,4)benzoxazine)-2,5,5'-trione; ADN-138; Spiro(pyrrolidine-3,6'(5'H)-pyrrolo(1,2,3-de)(1,4)benzoxazine)-2,5,5'-trione, 8'-chloro-2',3'-dihydro-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - ADN 138: 1
  - Oxazines: 9
    - ADN 138: 1

Related Diseases

1.	Hyperglycemia 05/01/1988 - "These results suggest that the increased polyol pathway activity in the hyperglycemia may be involved in the development of electroretinogram abnormalities similar to those in human diabetes; therefore, ADN-138 could be a useful drug for therapy of retinopathy in the early diabetic stage." 05/01/1988 - "Diabetic hyperglycemia-associated abnormalities were prevented and normalized by insulin or ADN-138, an aldose reductase inhibitor. " 05/01/1988 - "Polyol accumulation was prevented by insulin or ADN-138, and the elevated polyol level was reversed by insulin, ADN-138, or withdrawal of galactose in diabetic hyperglycemia and/or galactosemia. "
2.	Galactosemias (Galactosemia) 05/01/1988 - "Galactosemia-induced abnormalities were inhibited by ADN-138, and were reversed either by ADN-138 treatment or by withdrawal of galactose from the diet. " 05/01/1988 - "Polyol accumulation was prevented by insulin or ADN-138, and the elevated polyol level was reversed by insulin, ADN-138, or withdrawal of galactose in diabetic hyperglycemia and/or galactosemia. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Galactose (Galactopyranose)
3.	Aldehyde Reductase (Aldose Reductase)
4.	polyol

Related Therapies and Procedures

1.	Therapeutics