methyllycaconitine

natural toxin from seeds of Delphinium brownii; parasympathomimetic and mild nicotine antagonist; antagonist of alpha-conotoxin-MII sensitive presynaptic nicotinic receptors; potent insecticide; RN refers to (1alpha,4(S),6beta,14alpha,16beta)-isomer

Also Known As:

Networked: 52 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Yue: 2 articles (01/2022 - 12/2021)
2.	Di Cesare Mannelli, Lorenzo: 2 articles (01/2021 - 11/2020)
3.	Ghelardini, Carla: 2 articles (01/2021 - 11/2020)
4.	Lucarini, Elena: 2 articles (01/2021 - 11/2020)
5.	Zhang, Wei: 2 articles (01/2021 - 01/2019)
6.	Apryani, Evhy: 2 articles (02/2020 - 01/2020)
7.	Wang, Yong-Xiang: 2 articles (02/2020 - 01/2020)
8.	Wang, Zi-Ying: 2 articles (02/2020 - 01/2020)
9.	Iha, Higor A: 2 articles (01/2017 - 11/2016)
10.	Kinboshi, Masato: 2 articles (01/2017 - 11/2016)

Related Diseases

1.	Cognitive Dysfunction 08/01/2014 - "This study was undertaken to establish and characterize an in vivo model for cognitive disorder secondary to the blockade of α7 nAChR by its specific antagonist, methyllycaconitine (MLA). " 08/01/2014 - "Methyllycaconitine- and scopolamine-induced cognitive dysfunction: differential reversal effect by cognition-enhancing drugs." 01/01/2023 - "Methyllycaconitine, an antagonist for α7 nicotinic acetylcholine receptor, suppressed the rice-memolin-induced effect, suggesting that rice-memolin improved cognitive decline coupled to the acetylcholine system. " 05/01/2009 - "Quantitative measures of alpha7 nAChR by [(3)H]methyllycaconitine binding and Abeta concentration by enzyme-linked immunosorbent assay in SFC were compared across subjects with antemortem clinical classification of no cognitive impairment, mild cognitive impairment, or mild to moderate AD, and with postmortem neuropathological diagnoses. "
2.	Inflammation (Inflammations) 03/01/2016 - "Nicotine significantly increased survival rate of the infected mice, decreased myocardial inflammation, and improved the impairment of left ventricular function in murine coxsackievirus B3-induced myocarditis compared with methyllycaconitine. " 02/01/2016 - "Animals were treated with α7-nAChR agonists (AR-R17779 or A844606), with or without antagonists (COG133 or methyllycaconitine), and joint inflammation and pain were assessed. " 10/10/2013 - "The anti-hyperalgesic and anti-inflammatory action of PAT was assessed in rat models of inflammatory nociceptive hyperactivity (carrageenan and endotoxin) and in a mice air-pouch model for localized inflammation, respectively; the possible attenuation of PAT's effects by pretreatment with the α7-nAchR specific antagonist methyllycaconitine citrate (MLA) was also investigated. "
3.	Stroke (Strokes) 07/01/2012 - "Pharmacologic inhibition (methyllycaconitine IC(50): 0.2-0.6 nM) or genetic deletion of the α7nAChR significantly (P<0.05) attenuates the effect of prior stroke on lung injury and mortality caused by P. " 03/01/2014 - "Finally, administration of 15 mg/kg melatonin following the induction of photothrombotic stroke in vivo, reduced infarct size (50%), and improved motor skills; this effect was partially lost in 0.1 mg/kg methyllycaconitine (MLA, selective α7 nAChR antagonist)-treated mice. "
4.	Myocarditis (Carditis) 01/01/2014 - "These results show that nicotine protects mice from CVB3-induced viral myocarditis and that methyllycaconitine aggravates viral myocarditis in mice. " 01/01/2014 - "In a coxsackievirus B3 murine myocarditis model (Balb/c), nicotine and methyllycaconitine were used to stimulate and block the cholinergic anti-inflammatory pathway, respectively. " 03/01/2016 - "Nicotine significantly increased survival rate of the infected mice, decreased myocardial inflammation, and improved the impairment of left ventricular function in murine coxsackievirus B3-induced myocarditis compared with methyllycaconitine. " 01/01/2014 - "Because nicotine is a α7nAchR agonist and methyllycaconitine is a α7nAchR antagonist, we conclude that α7nAchR activation increases the phosphorylation of STAT3, reduces the expression of TNF-α and IL-6, and, ultimately, alleviates viral myocarditis. " 01/01/2014 - "In addition, levels of the signaling protein phosphorylated STAT3 were higher in the nicotine group and lower in the methyllycaconitine group compared with the untreated myocarditis group. "
5.	Infarction (Infarctions) 01/01/2021 - "We found PHA-568487 treatment reduced, methyllycaconitine increased the number of CD68+ cells in the peri-infarct and hippocampal regions, neuronal injury in the infarct region, sensorimotor and long-term memory dysfunctions. " 03/01/2014 - "Finally, administration of 15 mg/kg melatonin following the induction of photothrombotic stroke in vivo, reduced infarct size (50%), and improved motor skills; this effect was partially lost in 0.1 mg/kg methyllycaconitine (MLA, selective α7 nAChR antagonist)-treated mice. "

Related Drugs and Biologics

1.	Nicotine
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Melatonin
4.	Acetylcholine (Acetylcholine Chloride)
5.	Mecamylamine
6.	alpha7 Nicotinic Acetylcholine Receptor
7.	Dihydro-beta-Erythroidine
8.	Ethanol (Ethyl Alcohol)
9.	Inflammasomes
10.	5-HT3 Serotonin Receptors (5 HT3 Receptor)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Perioperative Period
3.	Vagotomy
4.	Spinal Injections
5.	Intraperitoneal Injections