beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

induced in preneoplastic stage of liver carcinogenesis promoted by orotic acid in rats; adds bisecting N-acetylglucosaminyl residue in beta 1,4 linkage to the beta-linked mannose of the core of asparagine-linked oligosaccharides; RefSeq NM_002409 (human); NM_010795 (mouse); NM_019239 (rat)

Also Known As:

GNT-III protein, human; GnT-III protein, mouse; MGAT3 protein, human; Mgat3 protein, mouse; Mgat3 protein, rat; N-acetylglucosaminyltransferase III; UDP-N-acetylglucosamine-beta-D-mannoside beta-1,4-N-acetylglucosaminyltransferase III; UDPGNAC-MAGtransferase III; UDPGNAC-glycopeptide beta4-N-acetylglucosaminyl transferase III; beta-1,4-N-acetylglucosaminyltransferase III; mannoside acetyl glucosaminyltransferase 3, rat; mannoside acetylglucosaminyltransferase 3, mouse; mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, human

Networked: 32 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - N-Acetylhexosaminyltransferases
        N-Acetylglucosaminyltransferases: 23
        beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase: 32

Experts

1.	Gu, Jianguo: 3 articles (01/2018 - 10/2006)
2.	Deng, Qinyin: 2 articles (10/2019 - 07/2019)
3.	Liu, Xiru: 2 articles (10/2019 - 07/2019)
4.	Kariya, Yoshinobu: 2 articles (01/2018 - 10/2006)
5.	Isaji, Tomoya: 2 articles (03/2016 - 10/2006)
6.	Miyoshi, Eiji: 2 articles (10/2006 - 08/2002)
7.	Taniguchi, Naoyuki: 2 articles (10/2006 - 08/2002)
8.	Xie, Lan: 1 article (10/2019)
9.	Yang, Zhongmei: 1 article (10/2019)
10.	Chen, Ying: 1 article (07/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "N-acetylglucosaminyltransferase III (GnT-III), encoded by the MGAT3 glycogene, is thought to be a tumor metastatic suppressor. " 11/15/2003 - "Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III." 07/01/2019 - "Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. " 10/01/2019 - "It has been shown that N-acetylglucosaminyltransferase III (GnT-III) participates in tumor invasion and metastasis as a suppressor; however, the expression of GnT-III and its role in normal pregnancy is unclear. " 01/01/2018 - "Interruption of β1,6GlcNAc-branching formation on β4-integrin with the introduction of bisecting GlcNAc by N-acetylglucosaminyltransferase III overexpression was correlated with suppression of cancer cell migration and tumorigenesis. "
2.	Neoplasm Metastasis (Metastasis) 07/01/2019 - "Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. " 10/01/2019 - "It has been shown that N-acetylglucosaminyltransferase III (GnT-III) participates in tumor invasion and metastasis as a suppressor; however, the expression of GnT-III and its role in normal pregnancy is unclear. " 09/12/1995 - "Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection." 07/01/1995 - "[Suppression of lung metastasis of B16 mouse melanoma cells by introduction of N-acetylglucosaminyltransferase III gene]." 03/11/2016 - "N-Acetylglucosaminyltransferase III (GnT-III), which catalyzes the addition of the bisecting GlcNAc branch on N-glycans, is usually described as a metastasis suppressor. "
3.	Ductal Carcinoma 04/01/2019 - "N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast." 04/01/2019 - "This study aimed to analyze the association between polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6), -T8, N-acetylglucosaminyltransferase III (GnT-III) expression, Phaseolus vulgaris-leucoagglutinin (PHA-L), wheat germ agglutinin (WGA) and peanut agglutinin (PNA) staining with clinic-histopathological factors from patients with pure ductal carcinoma in situ (DCIS) and DCIS with invasive ductal carcinoma (DCIS-IDC) of breast. "
4.	Noninfiltrating Intraductal Carcinoma (DCIS) 04/01/2019 - "This study aimed to analyze the association between polypeptide N-acetylgalactosaminyltransferase-6 (ppGalNAc-T6), -T8, N-acetylglucosaminyltransferase III (GnT-III) expression, Phaseolus vulgaris-leucoagglutinin (PHA-L), wheat germ agglutinin (WGA) and peanut agglutinin (PNA) staining with clinic-histopathological factors from patients with pure ductal carcinoma in situ (DCIS) and DCIS with invasive ductal carcinoma (DCIS-IDC) of breast. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2001 - "Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2." 06/01/1998 - "Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma." 11/24/1995 - "Transfection of N-acetylglucosaminyltransferase III gene suppresses expression of hepatitis B virus in a human hepatoma cell line, HB611." 09/14/1990 - "The N-acetylglucosaminyltransferase III activity toward the substrate is the highest in most rat tissues including primary rat hepatoma. " 12/15/1989 - "N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients."

Related Drugs and Biologics

1.	Peanut Agglutinin
2.	Wheat Germ Agglutinins
3.	Peptides (Polypeptides)
4.	plants leukoagglutinins
5.	Acetylglucosamine
6.	Polysaccharides (Glycans)
7.	Diethylnitrosamine (N-Nitrosodiethylamine)
8.	Messenger RNA (mRNA)
9.	Oligosaccharides
10.	Mannose (D-Mannose)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)