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2-tert-butyl-4-methylphenol

RN given refers to cpd with locants

Also Known As:

2-TBMP

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Cresols: 9
        Butylated Hydroxytoluene: 812
        2-tert-butyl-4-methylphenol: 8

Experts

1.	Fujisawa, Seiichiro: 1 article (11/2003)
2.	Saito, Masatoshi: 1 article (11/2003)
3.	Sakagami, Hiroshi: 1 article (11/2003)

Related Diseases

1.	Hyperplasia 09/15/1988 - "Treatment with CC, 2-tert-butyl-4-methylphenol, p-tert-butylphenol, or 4MP alone induced forestomach hyperplasia at incidences of 86.7, 40, 93.3, and 100%, respectively. " 10/01/1986 - "p-tert-Butylphenol and 2-tert-butyl-4-methylphenol induced pronounced hyperplasia and papillomas in the hamster forestomach. " 08/01/1986 - "Of these compounds, 2(3)-tert-butyl-4-methoxyphenol (BHA), 2-tert-butyl-4-methylphenol (TBMP) and p-tert-butylphenol (PTBP) strongly induced hyperplasia and tumorous lesions in the forestomach. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/01/2003 - "The cytotoxicity and apoptosis-inducing activity of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and 2-tert-butyl-4-methylphenol (BMP) and the mixture of BHA and BHT (BHA/BHT) (1:1, molar ratio) were investigated, using human promeylocytic leukemia cell lines (HL-60) and human squamous cell carcinoma cell lines (HSC-2). " 09/15/1988 - "The incidences of squamous cell carcinoma of the forestomach in MNNG-treated animals were significantly elevated by the diets containing CC (P less than 0.001), 2-tert-butyl-4-methylphenol (P less than 0.001), or p-tert-butylphenol (P less than 0.01), while the development of carcinoma in situ was inhibited by 4MP (P less than 0.01). " 02/01/1991 - "Histopathological examination revealed the incidences of forestomach squamous cell carcinomas in animals treated with N-methyl-N'-nitro-N-nitrosoguanidine followed by caffeic acid, catechol, butylated hydroxyanisole, 2-tert-butyl-4-methylphenol, and basal diet to be 27, 20, 13, 13, and 7%, respectively, whereas the incidence increased to 80% by the combined treatment with these four chemicals. "
3.	Carcinogenesis 01/01/1988 - "The effects of the antioxidants tetramethyl-p-phenylenediamine (TMPD), propyl gallate (PG), quercetin (QC), 2-tert-butyl-4-methylphenol (TBMP), tert-butylhydroquinone (TBHQ), 3,3'-thiodipropionic acid (TDPA), guaiac gum (GG) and caffeic acid (CA) on 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mammary gland, ear duct and forestomach carcinogenesis were examined in female Sprague--Dawley rats. "
4.	Papilloma (Papillomatosis) 10/01/1986 - "p-tert-Butylphenol and 2-tert-butyl-4-methylphenol induced pronounced hyperplasia and papillomas in the hamster forestomach. "
5.	Neoplasms (Cancer) 08/01/1990 - "The urinary bladder tumor-promoting potentials of the phenolic antioxidants, 2-tert-butyl-4-methylphenol (TBMP), propylparaben, catechol, resorcinol and hydroquinone, which are structurally related to butylated hydroxyanisole (BHA), were investigated in 170 male F344 rats. "

Related Drugs and Biologics

1.	Butylated Hydroxyanisole (BHA)
2.	1,2,3-tribromo-2-methylpropane
3.	catechol (pyrocatechol)
4.	butylphen
5.	Methylnitronitrosoguanidine (MNNG)
6.	Antioxidants
7.	caffeic acid
8.	Phenol (Carbolic Acid)
9.	Quercetin
10.	Propyl Gallate