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2,2-difluoroputrescine

derivative of naturally occurring cpd; can be used as probe in NMR imaging

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Putrescine: 919
        2,2-difluoroputrescine: 2
  - Biogenic Amines: 992
    - Biogenic Polyamines: 11
      - Putrescine: 919
        2,2-difluoroputrescine: 2

Related Diseases

1.

Neoplasms (Cancer)

01/01/1988 - "This indication has been inferred by studies in tumor-bearing animals, using 19F-NMR spectroscopy determination of tissue fluorospermidine and fluorospermine, formed biochemically from the precursors 2-fluoro or 2,2-difluoroputrescine, and which demonstrate preferential accumulation in tumor versus normal tissue. "
01/01/1988 - "8. Under identical experimental conditions the accumulation of chain-fluorinated polyamines in tumor tissue was more than twice as high with 2-fluoroputrescine as precursor than with the same dose of 2,2-difluoroputrescine. "
01/01/1988 - "9. From the fact that the accumulation of 6-fluoropolyamines is less selective in tumors than that of 6,6-difluoropolyamines, and from the lower detection sensitivity due to its lower fluorine content, we conclude that 2,2-difluoroputrescine is more advantageous as a tumor marker than 2-fluoroputrescine for detection with 19F-NMR spectroscopy.(ABSTRACT TRUNCATED AT 400 WORDS)"

Related Drugs and Biologics

1.	Tumor Biomarkers (Tumor Markers)
2.	Polyamines
3.	Fluorine
4.	2-fluoroputrescine