neurotensin (8-13)

binds in human brain to the same site as neurotensin but with higher affinity

Also Known As:

Arg-Arg-Pro-Tyr-Ile-Leu; arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine; L-Leucine, N-(N-(N-(1-(N2-L-arginyl-L-arginyl)-L-prolyl)-L-tyrosyl)-L-isoleucyl)-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Neurotensin: 1019
        neurotensin (8-13): 4
- Peptides: 82426
  - Neuropeptides: 6772
    - Neurotensin: 1019
      - neurotensin (8-13): 4
  - Peptide Fragments: 373
    - neurotensin (8-13): 4

Experts

1.	Andrzejewski, Kryspin: 1 article (10/2016)
2.	Jampolska, Monika: 1 article (10/2016)
3.	Kaczyńska, Katarzyna: 1 article (10/2016)
4.	Kleczkowska, Patrycja: 1 article (10/2016)
5.	Kogut, Ewelina: 1 article (10/2016)
6.	Lipkowski, Andrzej W: 1 article (10/2016)
7.	Sulejczak, Dorota: 1 article (10/2016)
8.	Zając, Dominika: 1 article (10/2016)

Related Diseases

1.	Neuroblastoma 10/01/1989 - "Neurotensin(8-13): comparison of novel analogs for stimulation of cyclic GMP formation in neuroblastoma clone N1E-115 and receptor binding to human brain and intact N1E-115 cells." 10/01/1989 - "A series of novel analogs of neurotensin (8-13) was synthesized, and a structure-activity study was done comparing the abilities of these peptides to stimulate intracellular cyclic GMP production in intact neuroblastoma clone N1E-115 and to inhibit the binding of [3H]neurotensin to these cells and to membranal preparations from human brain. " 10/07/1986 - "The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys8,Asn9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. "
2.	Inflammation (Inflammations) 10/10/2016 - "The objective of the study was to investigate the possibility of modulation of skin inflammation by topical treatment with a novel compound: an opioid-neurotensin hybrid peptide PK20 encompassing endomorphin-2 analog and modified fragment of neurotensin (8-13). "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 10/24/2023 - "We have recently shown that palmitoylation at the ε-amine of Lys7 in [99mTc]Tc-[Lys7]DT1 (DT1, N4-Gly-Arg-Arg-Pro-Tyr-Ile-Leu-OH, N4 = 6-(carboxy)-1,4,8,11-tetraazaundecane) led to the fully stabilized [99mTc]Tc-DT9 analog, displaying high uptake in human pancreatic cancer AsPC-1 xenografts but unfavorable pharmacokinetics in mice. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Neurotensin
3.	Cyclic GMP
4.	Opioid Analgesics (Opioids)
5.	endomorphin 2
6.	Adrenergic Agents (Adrenergic Drugs)
7.	Amines
8.	neuromedin N
9.	hydroxide ion
10.	xenopsin