chordin

component of notochord of sturgeoneous fishes; MW 100kDa

Also Known As:

CHRD protein, human; Chrd protein, mouse; chordin protein, Xenopus; chordin protein, zebrafish; chordin, human; chrd protein, zebrafish; organizer-specific secreted dorsalizing factor, Xenopus; Chordin

Networked: 52 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - chordin: 52
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - chordin: 52
  - Glycoproteins: 24834
    - chordin: 52
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - chordin: 52
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - chordin: 52

Experts

1.	Dressler, Gregory R: 3 articles (01/2019 - 10/2016)
2.	Grimley, Edward: 2 articles (01/2019 - 01/2017)
3.	Ranghini, Egon J: 2 articles (01/2019 - 10/2016)
4.	Soofi, Abdul: 2 articles (01/2017 - 10/2016)
5.	Wolf, Katherine I: 2 articles (01/2017 - 10/2016)
6.	Klingensmith, John: 2 articles (02/2009 - 08/2003)
7.	Bosserhoff, Anja-Katrin: 2 articles (11/2008 - 01/2005)
8.	Rothhammer, Tanja: 2 articles (11/2008 - 01/2005)
9.	Bachiller, Daniel: 2 articles (09/2007 - 08/2003)
10.	Maegawa, Shingo: 2 articles (09/2007 - 08/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "The Wnt pathway, which began to be uncovered in cancer biology studies, is crucial during the establishment of two signaling centers in Xenopus embryogenesis: Nieuwkoop center and the blastula chordin noggin expression center (BCNE). " 01/01/2023 - "The developmental gene Chordin is amplified and expressed in human cancers." 01/01/2022 - "Accumulating evidence suggests that dysregulation of Chordin-like 1 (CHRDL1) is associated with malignant biological behaviors in multiple cancers. " 02/01/2006 - "Chordin is underexpressed in ovarian tumors and reduces tumor cell motility." 02/14/2017 - "In this study, we demonstrated that the BMP antagonist Chordin-like 2 (CHRDL2) is upregulated in colorectal cancer (CRC) tissues, and that CHRDL2 levels correlate with clinical features of CRC patients, including tumor size, TNM staging, and tumor differentiation. "
2.	Squamous Cell Carcinoma of Head and Neck 07/01/2023 - "The aim of this study was to investigate the role and related mechanism of chordin-like 1 (CHRDL1) in oral squamous cell carcinoma (OSCC). " 07/01/2023 - "Study on the expression and function of chordin-like 1 in oral squamous cell carcinoma." 01/01/2022 - "Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma."
3.	Colorectal Neoplasms (Colorectal Cancer) 02/14/2017 - "In this study, we demonstrated that the BMP antagonist Chordin-like 2 (CHRDL2) is upregulated in colorectal cancer (CRC) tissues, and that CHRDL2 levels correlate with clinical features of CRC patients, including tumor size, TNM staging, and tumor differentiation. "
4.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "This study aimed to examine the role of chordin-like 2 (CHRDL2) in gastric cancer. " 01/01/2022 - "Chordin-Like 2: A Possible Therapeutic Target for Gastric Cancer by Affecting Cell Cycle and Proliferation."
5.	Micrognathism 01/01/2010 - "Studies show that mutant mice for chd (chordin) and nog (noggin) genes, which are modulators of the Bone Morphogenic Protein (BMP), had mandibular defects ranging from mandibular hypoplasia to micrognathia and agnathia. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Retinaldehyde (Retinal)
3.	Follistatin
4.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
5.	Biomarkers (Surrogate Marker)
6.	Messenger RNA (mRNA)
7.	von Willebrand Factor
8.	MEF2 Transcription Factors
9.	Decorin
10.	Cyclin A2

Related Therapies and Procedures

1.	Therapeutics