arachidonate 8-lipoxygenase

from sea whip coral Plexaura homomalla; catalyzes the conversion of arachidonic acid to a cyclized prostanoid with a PGA ring & the same side chains as the parent arachidonate

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alfardan, Rana: 1 article (04/2019)
2.	Guo, Changxiong: 1 article (04/2019)
3.	Nie, Daotai: 1 article (04/2019)
4.	Toth, Linda A: 1 article (04/2019)
5.	Hamanaka, Nobuyuki: 1 article (12/2005)
6.	Kawajiri, Hiroo: 1 article (12/2005)
7.	Murakami, Takashi: 1 article (12/2005)
8.	Piao, Yingshi: 1 article (12/2005)
9.	Takahashi, Yoshitaka: 1 article (12/2005)
10.	Yoshimoto, Tanihiro: 1 article (12/2005)

Related Diseases

1.	Renal Cell Carcinoma (Grawitz Tumor) 10/01/2000 - "In our laboratories DHPLC has been validated and used to genotype an Eker rat colony, to study the genetic profile of renal cell carcinomas, to quantitate expression of the keratinocyte lipid-binding protein gene in 8-lipoxygenase transgenic mice, and to detect polymorphisms and a point mutation in the tuberous sclerosis 2 tumor suppressor gene in t-haplotype mice."
2.	Tuberous Sclerosis 2 10/01/2000 - "In our laboratories DHPLC has been validated and used to genotype an Eker rat colony, to study the genetic profile of renal cell carcinomas, to quantitate expression of the keratinocyte lipid-binding protein gene in 8-lipoxygenase transgenic mice, and to detect polymorphisms and a point mutation in the tuberous sclerosis 2 tumor suppressor gene in t-haplotype mice."
3.	Papilloma (Papillomatosis) 02/01/1999 - "Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes."
4.	Neoplasms (Cancer) 12/01/1993 - "A unique reaction seen upon phorbol ester treatment of mouse skin is a strong induction of the enzyme 8-lipoxygenase, which might be involved in skin tumor development by catalyzing the generation of clastogenic metabolites thought to play a role in the conversion stage. "
5.	Human Influenza (Influenza) 04/12/2019 - "Impaired Recovery from Influenza A/X-31(H3N2) Infection in Mice with 8-Lipoxygenase Deficiency."

Related Drugs and Biologics

1.	Lipids
2.	Carrier Proteins (Binding Protein)
3.	Phorbol Esters
4.	Oxidants (Oxidizing Agents)
5.	Arachidonic Acid (Vitamin F)
6.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
7.	Lipoxygenase (Lipoxygenase-1)
8.	Enzymes
9.	Acids
10.	NF-KappaB Inhibitor alpha