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3,5-di-tert-butylchalcone 4'-carboxylic acid (CH 55)
inducer of differentiation; induces suppression of c-mos expression in teratocarcinoma cell; structure given in first source
Also Known As:
CH 55
;
CH55
; 4-(3-(3,5-di-t-butylphenyl)-3-oxo-1-propenyl)benzoic acid; CH-55
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ketones: 2618
Propiophenones: 1
Chalcones: 412
3,5-di-tert-butylchalcone 4'-carboxylic acid: 7
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
Chalcones: 412
3,5-di-tert-butylchalcone 4'-carboxylic acid: 7
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
Flavonoids: 9773
Chalcones: 412
3,5-di-tert-butylchalcone 4'-carboxylic acid: 7
Experts
1.
Chen, Bing-Fang
: 1 article (09/2016)
Related Diseases
1.
Leukemia
10/01/1990 - "
The retinobenzoic acids Am80, Am580 and Ch55 are synthetic stable analogs of retinoic acid (RA), and show very strong differentiation-inducing activity in human myelogeneous leukemia cell line HL-60.
"
04/01/1988 - "
The uptake of all-trans-retinoic acid (RA) and two new retinoids [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbamoyl )benzoic acid (Am80) and (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid (Ch55)] by HL-60 human promyelocytic leukemia cells was investigated.
"
2.
Teratocarcinoma
11/01/1987 - "
This indicates that Ch55 is a potent inducer of teratocarcinoma cells and suppresses c-mos expression.
"
11/01/1987 - "
Suppression of c-mos expression in teratocarcinoma cells with a new type of inducer of differentiation, 3,5-di-tert-butylchalcone 4'-carboxylic acid.
"
11/01/1987 - "
The treatment of 311 cells, a pluripotent mouse teratocarcinoma cell line, with a new type of inducer, 3,5-di-tert-butylchalcone 4'-carboxylic acid (Ch55), results in the suppression of the c-mos gene, accompanied by early marker changes associated with cell differentiation, i.e., the enhanced secretion of plasminogen activator and the decrease in peanut agglutinin receptors and glucose transport.
"
3.
Hypertrophic Cicatrix (Hypertrophic Scar)
01/01/2023 - "
Further investigation exhibited and elucidated the antifibrotic effects of Ch55 in vitro as well as showing antiscarring activity upon intradermal application in a preclinical rabbit ear hypertrophic scar model.
"
4.
Acute Promyelocytic Leukemia
06/01/1994 - "
The effects of retinoic acid (RA) analogues, Am80 and Ch55, on acute myeloblastic leukemia (AML) cells, acute promyelocytic leukemia (APL) cells, and normal bone marrow (BM) cells, were studied in vitro.
"
5.
Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/01/1994 - "
The effects of retinoic acid (RA) analogues, Am80 and Ch55, on acute myeloblastic leukemia (AML) cells, acute promyelocytic leukemia (APL) cells, and normal bone marrow (BM) cells, were studied in vitro.
"
Related Drugs and Biologics
1.
Tretinoin (Retinoic Acid)
2.
tamibarotene
3.
3,5-di-tert-butylchalcone 4'-carboxylic acid (CH 55)
4.
Benzoic Acid (Potassium Benzoate)
5.
Retinoids
6.
Plasminogen Activators (Plasminogen Activator)
7.
Glucose (Dextrose)
8.
DNA (Deoxyribonucleic Acid)
9.
Acids
10.
Am 580 (Am580)