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agelasine B

isolated from orange-colored sea sponge; structure given in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        agelasine B: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - agelasine B: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - agelasine B: 2

Experts

1.	Cheng, Yiyu: 1 article (05/2013)
2.	Fang, Fengkai: 1 article (05/2013)
3.	Ge, Zhiwei: 1 article (05/2013)
4.	Sun, Lijuan: 1 article (05/2013)
5.	Wang, Yi: 1 article (05/2013)
6.	Xiao, Shun: 1 article (05/2013)
7.	Zhang, Wen: 1 article (05/2013)
8.	Zhang, Yufeng: 1 article (05/2013)
9.	Arvelo, Francisco: 1 article (01/2012)
10.	Benaim, Gustavo: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "The reproduction of the effects of agelasine B on cell viability and on the [Ca(2+)]( I ) obtained on SKBr3 and PC-3 cancer cells strongly suggests the generality of the mechanism of action of this toxin." 01/01/2012 - "In search for new drugs derived from natural products for the possible treatment of cancer, we studied the action of agelasine B, a compound purified from a marine sponge Agelas clathrodes. " 05/13/2013 - "In particular, two diterpenoid derivatives, agelasine B and (-)-agelasine D, were identified for the first time as anti-tumor compounds from the sponge Agelas mauritiana, showing a considerable activity toward MCF-7 cells (IC50 values of 7.84±0.65 and 10.48±0.84 μM, respectively). "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2012 - "Agelasine B was purified from a marine sponge Agelas clathrodes and assayed for cytotoxicity by MTT on two human breast cancer cells (MCF-7 and SKBr3), on a prostate cancer cells (PC-3) and on human fibroblasts. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "Upon agelasine B treatment, cell viability of both human breast cancer cell lines was one order of magnitude lower as compared with fibroblasts (IC(50) for MCF-7 = 2.99 μM; SKBr3: IC(50) = 3.22 μM vs. fibroblasts: IC(50) = 32.91 μM), while the IC(50) for PC-3 IC(50) = 6.86 μM. " 01/01/2012 - "The marine sponge toxin agelasine B increases the intracellular Ca(2+) concentration and induces apoptosis in human breast cancer cells (MCF-7)." 01/01/2012 - "Agelasine B was purified from a marine sponge Agelas clathrodes and assayed for cytotoxicity by MTT on two human breast cancer cells (MCF-7 and SKBr3), on a prostate cancer cells (PC-3) and on human fibroblasts. "

Related Drugs and Biologics

1.	Diterpenes
2.	agelasine D