fertilization antigen

causes reduction of fertility in actively immunized rabbits; involved in involuntary immunofertility in humans; MW 47kDa & 23kDA, dimeric & monomeric forms, respectively

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Naz, Rajesh K: 1 article (01/2002)

Related Diseases

1.	Male Infertility (Male Sterility) 10/01/1999 - "The exciting findings from the recent trial in immunoinfertile couples indicate that the FA-1 antigen may have clinical application in the treatment of male infertility. "
2.	Infertility (Sterility) 01/01/2002 - "Among these, the fertilization antigen (FA-1) is particularly interesting, because it is involved in immuno-infertility in humans. " 02/01/1990 - " PH-30 from guinea pigs and M29 from mouse participate in sperm-egg membrane fusion, as does fertilization antigen I from human and mouse sperm which is know to cause infertility. " 01/01/1988 - "The fertilization antigen (FA-1): applications in immunocontraception and infertility in humans."
3.	Herpes Zoster 08/01/1992 - "Fertilization antigen does not exhibit proteolytic or acrosin activity; however, its mAb completely blocks human sperm penetration of zona-free hamster ova. " 05/01/1995 - "Also, the monoclonal Fab' antibodies to FA-1 antigen and phosphotyrosine residues significantly (P < 0.05) reduced sperm-zona pellucidae and the antibodies were preincubated with sperm before insemination and not vice versa. " 08/01/1992 - "To determine if human sperm surface fertilization antigen exhibits proteolytic or acrosin activity and to investigate the mechanism(s) whereby monoclonal antibody (mAb) to fertilization antigen inhibits human sperm penetration of zona-free hamster ova. " 06/01/1992 - "To investigate the effects of antibodies to well-defined sperm surface antigens (the fertilization antigen [FA-1] and germ-cell antigen [GA-1]) and nuclear antigen (protamine) on human sperm-zona interaction. "

Related Drugs and Biologics

1.	Antibodies
2.	Nuclear Antigens (Extractable Nuclear Antigens)
3.	Phosphotyrosine
4.	Protamines (Protamine Sulfate)
5.	Surface Antigens (Surface Antigen)
6.	Antigens
7.	Monoclonal Antibodies
8.	Acrosin
9.	G(A1) ganglioside (GA(1))

Related Therapies and Procedures

1.	Immunologic Contraception (Immunocontraception)