casticin

04/01/2012 - "In this study, we investigated whether vitexicarpin (5-100 nM) prevented the TNF-α-induced vascular inflammation process in human umbilical vein endothelial cells (HUVEC). "
06/01/2020 - "Casticin also significantly regulated oxidative stress and reduced inflammation in the cartilage of mice with OA. "
12/02/2014 - "RAW264.7 cells were pretreated with various concentrations of casticin (0.3-10μM), and then treated with LPS to induce inflammation. "
04/01/2012 - "In conclusion, vitexicarpin significantly reduced vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells."
09/01/2007 - "Casticin has significant anti-inflammatory effect on acute inflammation, which is probably related to the inhibition of the inflammation factors. "

09/01/2018 - "Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proven effective in preventing tumor progression in previous studies. "
03/01/2020 - "Most studies have shown that casticin has a strong anti-proliferation activity against various tumor cells. "
02/22/2019 - "In the present study, we investigated the anti-neoplastic effects of casticin (CTC), identified from the plant Vitex rotundifolia L., alone and/or in combination with BEZ-235, a dual Akt/mTOR inhibitor in human tumor cells. "
01/01/2016 - "In the in vivo studies, results from immuno-deficient nu/nu mice bearing the A375.S2 tumor xenograft indicated that casticin significantly suppressed tumor growth based on tumor size and weight decreases. "
12/02/2014 - "Previous studies found that casticin, isolated from Vitex rotundifolia, could induce apoptosis of tumor cells. "

07/05/2018 - "Casticin (3', 5-dihydroxy-3, 4', 6, 7-tetramethoxyflavone), one of the main components from Vitex rotundifolia L., was reported to possess several pharmacological properties, including anti-inflammatory, hepatoprotective, anticancer, anti-asthma activities. "
07/01/2018 - "In conclusion, the results indicated that casticin might be a novel therapeutic strategy for the treatment of asthma."
07/01/2018 - "However, the effect of casticin on asthma remains unknown. "
07/14/2011 - "These results suggest that casticin has the potential for use in the treatment of allergic asthma."
01/01/2018 - "Protective Effects of Casticin From Vitex trifolia Alleviate Eosinophilic Airway Inflammation and Oxidative Stress in a Murine Asthma Model."

09/01/2020 - "However, the effect of casticin on synovial fibrosis in KOA is not clear. "
09/01/2020 - "Casticin, a compound purified from the Chinese herb Viticis Fructus, has been proved effective in preventing inflammation and fibrosis in previous studies. "
09/01/2020 - "In present study, we aimed to investigate how did casticin affect synovial fibrosis on monoiodoacetic acid (MIA)-induced KOA in rats. "
09/01/2020 - "Our data suggested that casticin improved hypoxia and inflammation in synovium tissue, as well the synovial fibrosis in rats. "
08/22/2017 - "In vivo experiments showed that treatment with casticin alone had no toxic effect while significantly attenuating CCl4-or BDL-induced liver fibrosis, as indicated by reductions in the density of fibrosis, hydroxyproline content, expression of α-SMA and collagen α1(I) mRNA. "

01/01/2019 - "Casticin is a newly emerging selective PI3K inhibitor with potential for use as a targeted therapeutic treatment for nasopharyngeal carcinoma. "
01/01/2019 - "The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for targeted use as a medicine. "
02/26/2021 - "Correction to: Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase."
01/01/2019 - "Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase."
01/01/2019 - "Moreover, casticin was observed to affect the self-renewal ability of the nasopharyngeal carcinoma cell lines, and a combination of casticin with BYL719 was observed to induce a decrease in the level of the phosphorylation of mTORC1 downstream targets in BYL719-insensitive NPC cell lines. "