2'-fluoro-5-ethylarabinosyluracil (FEAU)

Also Known As:

FEAU; 2'-fluoro-5-ethyl-1-beta-D-ara U; 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil

Networked: 19 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Uridine: 1186
        Arabinofuranosyluracil: 37
        2'-fluoro-5-ethylarabinosyluracil: 19
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Uridine: 1186
      - Arabinofuranosyluracil: 37
        2'-fluoro-5-ethylarabinosyluracil: 19
  - Arabinonucleosides: 1
    - Arabinofuranosyluracil: 37
      - 2'-fluoro-5-ethylarabinosyluracil: 19

Experts

1.	Serganova, Inna: 4 articles (08/2009 - 09/2004)
2.	Alauddin, Mian: 3 articles (10/2011 - 05/2007)
3.	Alauddin, Mian M: 3 articles (01/2011 - 01/2007)
4.	Gelovani, Juri G: 3 articles (01/2011 - 01/2007)
5.	Soghomonyan, Suren: 3 articles (01/2011 - 09/2004)
6.	Blasberg, Ronald: 3 articles (08/2009 - 09/2004)
7.	Doubrovin, Michael: 3 articles (08/2009 - 09/2004)
8.	Gelovani, Juri: 3 articles (08/2009 - 09/2004)
9.	Cai, Shangde: 3 articles (04/2008 - 09/2004)
10.	Conti, Peter S: 2 articles (07/2011 - 06/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2009 - "Presence of virus-infected tumor cells was successfully imaged with [(18)F]FEAU-PET, that identified 8 out of 8 tumor-positive nodes. " 01/01/2009 - "The presence of tumor-targeting and reporter-expressing virus was assessed by [(18)F]-2'-fluoro-2'-deoxy-1-beta-D-beta-arabinofuranosyl-5-ethyluracil ([(18)F]FEAU) positron emission tomography (PET) and confirmed by histochemical assays. " 04/15/2008 - "A linear correlation was shown between the number of viable bacteria in tumors and the accumulation of [18F]FEAU, but not [18F]FDG. " 04/15/2008 - "Imaging with [18F]FDG provided lower contrast than [18F]FEAU due to high FDG accumulation in control (nontreated) tumors and surrounding tissues. " 06/01/2007 - "Uptake of [3H]FEAU in transduced tumors was 9.98+/-1.99, 5.0-fold higher (p<0.001) than in wild type tumors. "
2.	Hyperthermia 12/27/2021 - "Our results showed that 4.32 ± 0.79 nm sized FeAu NPs were superparamagnetic in nature with a saturation magnetization (Ms) of 5.8 emu/g and elevated the media temperature to 45 °C, confirming the prospect to deliver hyperthermia. " 01/01/2023 - "FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). " 10/13/2022 - "Our results confirmed that Ti@FeAu core-shell nanoparticles were superparamagnetic, improved the negative contrast effect on glioma, and exhibited a temperature elevation of 12° C upon magnetic stimulation, which implies potential applications in magnetic resonance imaging (MRI) and hyperthermia-based cancer therapy. " 10/13/2022 - "Here, we have synthesized Ti@FeAu core-shell nanoparticles conjugated with angiopep-2 (Ti@FeAu-Ang nanoparticles) to target glioma cells and treat brain cancer via hyperthermia produced by a magnetic field. " 01/01/2023 - "Theranostic doxorubicin encapsulated FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and medical imaging in oral carcinoma."
3.	Mouth Neoplasms (Oral Cancer) 12/27/2021 - "Oral Cancer Theranostic Application of FeAu Bimetallic Nanoparticles Conjugated with MMP-1 Antibody." 01/01/2023 - "Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment."
4.	Glioma (Gliomas) 10/13/2022 - "Our results confirmed that Ti@FeAu core-shell nanoparticles were superparamagnetic, improved the negative contrast effect on glioma, and exhibited a temperature elevation of 12° C upon magnetic stimulation, which implies potential applications in magnetic resonance imaging (MRI) and hyperthermia-based cancer therapy. " 10/13/2022 - "Here, we have synthesized Ti@FeAu core-shell nanoparticles conjugated with angiopep-2 (Ti@FeAu-Ang nanoparticles) to target glioma cells and treat brain cancer via hyperthermia produced by a magnetic field. "
5.	Sarcoma (Soft Tissue Sarcoma) 10/01/2011 - "This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC) as a new potential positron emission tomography (PET) probe for HSV1-tk gene imaging and compared it with 2'-deoxy-2'-[(18)F]fluoro-5-iodo-1-β-D-arabinofuranosyluracil ((18)F-FIAU) and 2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-β-D-arabinofuranosyluracil((18)F-FEAU) (thymidine analogues) in an NG4TL4-WT/STK sarcoma-bearing mouse model. "

Related Drugs and Biologics

1.	fialuridine
2.	Thymidine
3.	Arabinofuranosyluracil (Ara U)
4.	Antiviral Agents (Antivirals)
5.	Firefly Luciferases
6.	Interferon-beta
7.	Transforming Growth Factor beta (TGF-beta)
8.	Nucleosides
9.	Luciferases
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Precision Medicine
3.	Intravenous Injections
4.	Induced Hyperthermia (Thermotherapy)
5.	Drug Therapy (Chemotherapy)