aplysianin E
isolated from supernatant of eggs of sea hare, Aplysia kurodai; MW: 250 kD
Also Known As:
aplysianin-E; Aplysianin E
Networked: 1
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Related Diseases
| 1. | Neoplasms (Cancer)
11/01/1987
- " An antitumor factor, aplysianin E, inducing tumor lysis was purified to apparent homogeneity from the supernatant of a homogenate of eggs of the sea hare Aplysia kurodai. " 11/01/1987
- " Aplysianin E also prolonged the survival of mice bearing syngeneic MM46 ascites or solid tumors. " 11/01/1987
- " Tumor lysis by aplysianin E was inhibited by N-acetylneuraminic acid, suggesting that recognition of the sugar moiety is a key step in cytolysis induced by aplysianin E. " 11/01/1987
- " Aplysianin E was labile on treatments with heat, low pH, urea, guanidine, sodium lauryl sulfate, and periodate, but not with proteases or organic solvents, Aplysianin E completely inhibited the syntheses of DNA, RNA, and protein by tumor cells within 2 h and caused their complete cytolysis within 15 h. "
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| 2. | Ascites
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