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AR 12463
inhibits formation of thromboxane B2
Also Known As:
AR-12463; Ethanol, 2-(pentyl(5-(1-piperidinyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-yl)amino)-
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Triazoles: 1533
Trapidil: 134
AR 12463: 3
Pyrimidines: 510
Trapidil: 134
AR 12463: 3
Related Diseases
1.
Hypercholesterolemia
01/01/1991 - "
The area of aorta covered with fatty streaks was significantly smaller in group 3 versus group 1. The results of this study indicate that treatment of rabbits with AR 12463 while feeding a cholesterol-rich diet prevents hypercholesterolemia as well as the cholesterol incorporation into tissues.
"
2.
Hepatocellular Carcinoma (Hepatoma)
10/01/1991 - "
The effect of trapidil (Rocornal) and its derivatives AR 12456 and AR 12463 on endogenous cholesterol synthesis and on cholesterol esterification rate was studied in human skin fibroblasts (HSF), in human hepatoma cell line Hep G2 and in primary culture of peritoneal macrophages from mouse (PMM).
"
09/01/1989 - "
The effect of trapidil (RocornalR) and some of its newly developed derivatives (AR 12456, AR 12463, AR 12465, AR 12464) on the receptor-mediated low density lipoprotein (LDL) binding, uptake and degradation was studied in human skin fibroblasts (HSF) and in human hepatoma cell line Hep G2.
"
3.
Atherosclerosis
01/01/1991 - "
The mode of action of AR 12463 on serum and tissue lipids as well as on the development of atherosclerosis is discussed.
"
01/01/1991 - "
Influence of the trapidil derivative AR 12463 on serum and tissue lipids and development of aortic lesions during experimental atherosclerosis in rabbits.
"
4.
Body Weight (Weight, Body)
01/01/1991 - "
Daily administration of the trapidil derivative AR 12463 (20 mg/kg body weight i.p.) to cholesterol-fed rabbits diminished statistically significantly the increase in serum total cholesterol.
"
Related Drugs and Biologics
1.
Cholesterol
2.
Trapidil
3.
AR 12456
4.
LDL Lipoproteins (beta Lipoproteins)
5.
Lipids
6.
oxidized low density lipoprotein
7.
AR 12465