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anacrotine
isolated from several species of Crotalaria; structure given in first source
Also Known As:
crotalaburnine
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Pyrrolizidine Alkaloids: 290
anacrotine: 2
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Pyrrolizidine Alkaloids: 290
anacrotine: 2
Related Diseases
1.
Necrosis
01/01/1987 - "
Anacrotine caused acute centrilobular necrosis and congestion of the liver when 125 mg/kg or more was given i.p., but oral doses (up to 180 mg/kg) caused relatively little liver necrosis.
"
2.
Inflammation (Inflammations)
08/01/1974 - "
The effect was compared with the activity of hydrocortisone, phenylbutazone, sodium salicylate and cyproheptadine against different types of inflammation.2 Crotalaburnine (40 mg/kg s.c.
"
3.
Granuloma
08/01/1974 - "
Inhibitory effect of a pyrrolizidine alkaloid, crotalaburnine, on rat paw oedema and cotton pellet granuloma.
"
08/01/1974 - "
In a parallel series cyproheptadine (10 mg/kg oral and i.p., respectively) produced significant inhibition of 5-hydroxytryptamine- and dextran-induced oedema, while phenylbutazone (100 mg/kg i.p.) failed to produce any significant inhibition of prostaglandin-induced oedema.6 Against cotton-pellet granuloma crotalaburnine, in half the dose of hydrocortisone, produced similar inhibition while phenylbutazone produced much greater inhibition in five times the dose of crotalaburnine given orally.7 The possible mode of action of crotalaburnine as an anti-oedema agent is discussed.
"
Related Drugs and Biologics
1.
Sodium Salicylate (Salicylate, Sodium)
2.
Pyrrolizidine Alkaloids
3.
Prostaglandins
4.
Phenylbutazone (Butazolidin)
5.
Hydrocortisone (Cortisol)
6.
Dextrans (Dextran)
7.
Cyproheptadine (Periactin)