desflurane (I 653)

volatile anesthetic that differs from isoflurane by substitution of a fluorine atom for the chlorine found on the alpha-ethyl component of isoflurane; MF: CF2-O-CFH-CF3; produces anesthetic preconditioning to protect the myocardium against infarction

Also Known As:

Networked: 405 relevant articles (17 outcomes, 59 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Roewer, Norbert: 12 articles (01/2012 - 09/2006)
2.	Kehl, Franz: 11 articles (01/2012 - 09/2006)
3.	Redel, Andreas: 11 articles (01/2012 - 09/2006)
4.	Lange, Markus: 10 articles (04/2011 - 09/2006)
5.	Stumpner, Jan: 9 articles (01/2012 - 10/2009)
6.	Smul, Thorsten M: 9 articles (04/2011 - 09/2006)
7.	Lotz, Christopher: 6 articles (04/2011 - 10/2009)
8.	Hoffman, William E: 4 articles (10/2007 - 06/2002)
9.	Tsai, Shen-Kou: 4 articles (12/2004 - 04/2004)
10.	Zhu, Biao: 3 articles (11/2015 - 05/2008)

Related Diseases

1.	Anoxia (Hypoxia) 01/01/2006 - "We conclude that 6% desflurane, a clinically useful concentration (1 minimal alveolar concentration), improved the recovery of postsynaptic evoked responses in rat hippocampal slices after 3.5 minutes of hypoxia. " 11/01/2015 - "In this study, we aimed to assess whether desflurane preconditioning protects human umbilical vein endothelial cells (HUVECs) agaist anoxia/reoxygenation (A/R) injury. " 05/01/2008 - "In this study, ECV304 (a human umbilical vein endothelial cell line) was preconditioned with 30 min desflurane (1 minimal alveolar concentration), after 15 min washout, 30 min anoxia, and 60 min reoxygenation was performed. " 11/01/2015 - "Desflurane preconditioning protects human umbilical vein endothelial cells against anoxia/reoxygenation by upregulating NLRP12 and inhibiting non-canonical nuclear factor-κB signaling." 01/01/2013 - "Desflurane preconditioning caused phosphorylation and nuclear translocation of NF-κB before anoxia, on the contrary, induced the synthesis of IκBα and inhibition of NF-κB after reoxygenation. "
2.	Malignant Hyperthermia 01/01/2003 - "Animal-experimental studies demonstrate desflurane's trigger effect for malignant hyperthermia (MH). " 07/01/2003 - "Is desflurane a "weak" trigger of malignant hyperthermia?" 02/01/2001 - "[Malignant hyperthermia in a pig anesthesized with desflurane]." 04/01/1998 - "A case of suspected malignant hyperthermia during desflurane administration." 08/01/1997 - "A case of suspected malignant hyperthermia during desflurane administration."
3.	Postoperative Nausea and Vomiting (PONV) 01/01/1999 - "Our study was designed to evaluate the effect of the combination of desflurane with N2O versus desflurane alone on postoperative nausea and vomiting (PONV) in a subgroup of female patients and PONV was considered as the primary endpoint. " 01/01/1999 - "The objective of the study was to determine the incidence of postoperative nausea and vomiting after general anaesthesia with desflurane. " 10/01/2006 - "Regression modeling demonstrated that female sex (OR=3.0, P=0.005) and use of desflurane (OR=2.8, P=0.003) were significant independent predictors of PONV. " 01/01/1999 - "The incidence of PONV was significantly higher in the group of patients receiving desflurane in N2O-O2 mixture compared with the group receiving desflurane in AIR-O2 mixture. " 09/01/1998 - "We found a significantly higher incidence of postoperative nausea and vomiting in those patients receiving desflurane. "
4.	Pain (Aches) 01/01/2015 - "Group B and group L saved 36 % and 25 % desflurane per unit time respectively when compared with group C (p < 0.001and p < 0.05) while the mean pain scores and analgesic requirements the first day after surgery were higher in group C (p < 0.05). " 11/01/2003 - "Although pain sensitivity may differ in women versus men, MAC of desflurane does not." 04/01/2005 - "Patients receiving desflurane reported faster recovery from anesthesia but an earlier and more intense perception of pain after surgery." 02/01/1995 - "Desflurane, with the characteristics of rapid onset and minimal metabolism, may provide better analgesia and safety for labour pain control. " 04/01/1998 - "The incidence of pain and other minor postoperative complications was similar between the groups except for sore throat which was higher in the desflurane group. "
5.	Postoperative Pain 01/01/2005 - "Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: the effect on postoperative pain, pulmonary function, and tracheal extubation times." 01/01/2015 - "Tapering of remifentanil at the end of surgery decreased postoperative pain scores immediately after thyroidectomy with desflurane and high-dose remifentanil anesthesia. " 11/01/2008 - "Postoperative pain and analgesic requirements after anesthesia with sevoflurane, desflurane or propofol." 09/01/2012 - "The incidence of EA and the modified Children's Hospital of Eastern Ontario Pain Scale were significantly lower in group K1.0 and group K0.5 compared to group C, but there was no significant difference between groups K1.0 and K0.5. In children undergoing brief ophthalmic surgery with desflurane anesthesia, ketamine 1.0 mg/kg administered before entering the operating room reduced separation anxiety, postoperative pain, and incidence of EA without delay in recovery." 01/01/2015 - "This study was designed to investigate whether stepwise tapering of remifentanil at the end of surgery could decrease postoperative pain scores and requirements of rescue analgesics after remifentanil-desflurane anesthesia in patients with thyroidectomy. "

Related Drugs and Biologics

1.	sevoflurane (Ultane)
2.	Propofol (Diprivan)
3.	Anesthetics (Anesthetic Agents)
4.	Isoflurane
5.	remifentanil (Ultiva)
6.	Analgesics (Analgesic Drugs)
7.	Alfentanil (Alfenta)
8.	Morphine (MS Contin)
9.	Halothane (Fluothane)
10.	Sufentanil (Sufenta)

Related Therapies and Procedures

1.	Anesthesia
2.	Laparoscopic Cholecystectomy
3.	Hypnosis (Mesmerism)
4.	Induced Heart Arrest (Cardioplegia)
5.	Craniotomy