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lodelaben
Also Known As:
2-chloro-4-(1-hydroxyoctadecyl)benzoic acid; SC 39026; SC-39026; declaben
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Chlorobenzoates
lodelaben: 3
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
Chlorobenzoates
lodelaben: 3
Related Diseases
1.
Pulmonary Hypertension
12/01/1991 - "
To determine whether inhibition of elastolytic activity might prevent this vascular change in other conditions producing pulmonary hypertension, we administered SC-39026 to rats during a 10-day exposure to chronic hypobaric hypoxia.
"
10/01/1991 - "
Our previous studies showed that increased pulmonary artery elastolytic activity is associated with monocrotaline-induced pulmonary hypertension in rats, and the latter is reduced by the elastase inhibitor SC-39026.
"
12/01/1991 - "
Previously in rats injected with the toxin monocrotaline and administered SC-39026, a serine elastase inhibitor, pulmonary hypertension was decreased in association with reduced muscularization of peripheral pulmonary arteries.
"
04/01/1989 - "
SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats.
"
2.
Hypertrophy
04/01/1989 - "
Failure to inhibit medial hypertrophy with SC-39026 suggests that a different mechanism or a different elastase may be involved in this structural change.
"
04/01/1989 - "
SC-39026 did not significantly reduce monocrotaline-induced medial hypertrophy of muscular arteries, endothelial injury, and associated subendothelial edema; nor was there a significant increase in the proportion of the medial elastin, although a trend was apparent.
"
3.
Edema (Dropsy)
04/01/1989 - "
SC-39026 did not significantly reduce monocrotaline-induced medial hypertrophy of muscular arteries, endothelial injury, and associated subendothelial edema; nor was there a significant increase in the proportion of the medial elastin, although a trend was apparent.
"
4.
Hypoxia (Hypoxemia)
12/01/1991 - "
Elastolytic activity was fourfold higher in central pulmonary arteries 2 days after hypoxia when compared with values in control vessels, and the activity was inhibited by SC-39026.
"
12/01/1991 - "
SC-39026 reduced the number of muscularized arteries and the level of pulmonary arterial pressure during exposure to chronic hypoxia.
"
12/01/1991 - "
To determine whether inhibition of elastolytic activity might prevent this vascular change in other conditions producing pulmonary hypertension, we administered SC-39026 to rats during a 10-day exposure to chronic hypobaric hypoxia.
"
Related Drugs and Biologics
1.
Monocrotaline
2.
Pancreatic Elastase (Elastase)
3.
Serine (L-Serine)
4.
Elastin